From gross anatomy to the nanomorphome: stereological tools provide a paradigm for advancing research in quantitative morphomics

Journal of Anatomy
Terry M Mayhew, John Milton Lucocq

Abstract

The terms morphome and morphomics are not new but, recently, a group of morphologists and cell biologists has given them clear definitions and emphasised their integral importance in systems biology. By analogy to other '-omes', the morphome refers to the distribution of matter within 3-dimensional (3D) space. It equates to the totality of morphological features within a biological system (virus, single cell, multicellular organism or populations thereof) and morphomics is the systematic study of those structures. Morphomics research has the potential to generate 'big data' because it includes all imaging techniques at all levels of achievable resolution and all structural scales from gross anatomy and medical imaging, via optical and electron microscopy, to molecular characterisation. As with other '-omics', quantification is an important part of morphomics and, because biological systems exist and operate in 3D space, precise descriptions of form, content and spatial relationships require the quantification of structure in 3D. Revealing and quantifying structural detail inside the specimen is achieved currently in two main ways: (i) by some form of reconstruction from serial physical or tomographic slices or (ii) by using ran...Continue Reading

References

Sep 1, 1990·Journal of Microscopy·T MattfeldtP Möller
Sep 1, 1987·Journal of Microscopy·H J Gundersen, E B Jensen
Jun 1, 1986·Journal of Microscopy·A J BaddeleyL M Cruz-Orive
May 1, 1982·Journal of Microscopy·B M StringerE D Williams
Jun 1, 1993·Clinical Otolaryngology and Allied Sciences·T M Mayhew, P O'Flynn
Jan 1, 1996·Journal of Structural Biology·J R KremerJ R McIntosh
Jan 1, 1996·The Journal of Comparative Neurology·C B Saper
May 29, 1999·Journal of Microscopy·H J Gundersen Nielsen J
Sep 19, 2000·Journal of Magnetic Resonance Imaging : JMRI·Q Y GongN Roberts
Jul 12, 2002·The EMBO Journal·Margaret A LawlorDario R Alessi
Sep 17, 2002·Journal of Microscopy·H J G Gundersen
Jun 1, 1964·The Journal of Cell Biology·E R WEIBEL, B W KNIGHT
Feb 26, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·D M HydeH J G Gundersen
Jan 18, 2005·Trends in Cell Biology·Richard McIntoshDavid Mastronarde
Apr 29, 2005·Journal of Anatomy·Simon McCullough, John Lucocq
Jul 29, 2006·Journal of Microscopy·J R Nyengaard, H J G Gundersen
Aug 10, 2006·Nature Methods·Michael J RustXiaowei Zhuang
Sep 19, 2006·Biophysical Journal·Samuel T HessMichael D Mason
Jun 30, 2007·Journal of Structural Biology·A E YakushevskaA J Koster
Jul 4, 2007·Journal of Structural Biology·Dimitri VanheckeMatthias Ochs
Nov 16, 2007·Basic Research in Cardiology·Judith Christina EiseleChristian Mühlfeld
Dec 11, 2007·Developmental Biology·Svetlana SurkovaJohn Reinitz
Dec 27, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Christian MühlfeldBarbara Rothen-Rutishauser
Jun 17, 2008·Histochemistry and Cell Biology·Terry M Mayhew, John M Lucocq
Nov 4, 2008·Ultramicroscopy·Kazuhiro AoyamaAtsuo Miyazawa
Dec 23, 2008·Trends in Biochemical Sciences·Andrew LeisWolfgang Baumeister
Dec 31, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Juliane KnustJens R Nyengaard
Jan 7, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·John Milton Lucocq, Christian Gawden-Bone
Jan 13, 2009·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Terry M MayhewMatthias Ochs
Jan 16, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Christian MühlfeldTerry M Mayhew
Jun 30, 2009·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Roman I Koning, Abraham J Koster
Feb 5, 2010·American Journal of Respiratory and Critical Care Medicine·Connie C W HsiaUNKNOWN ATS/ERS Joint Task Force on Quantitative Assessment of Lung Structure

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Citations

Oct 1, 2016·Histochemistry and Cell Biology·Matthias OchsChristian Mühlfeld
Dec 17, 2016·Cell and Tissue Research·Ewald R Weibel
Apr 22, 2017·Histochemistry and Cell Biology·Sophie FergusonJohn Milton Lucocq
Jun 12, 2020·Scientific Reports·Sophie MoittiéCatrin Sian Rutland
Oct 15, 2020·Histochemistry and Cell Biology·Lars KnudsenMatthias Ochs

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