From Hayflick to Walford: the role of T cell replicative senescence in human aging

Experimental Gerontology
Rita B Effros

Abstract

The immunologic theory of aging, proposed more than 40 years ago by Roy Walford, suggests that the normal process of aging in man and in animals is pathogenetically related to faulty immunological processes. Since that time, research on immunological aging has undergone extraordinary expansion, leading to new information in areas spanning from molecular biology and cell signaling to large-scale clinical studies. Investigation in this area has also provided unexpected insights into HIV disease, many aspects of which represent accelerated immunological aging. This article describes the initial insights and vision of Roy Walford into one particular facet of human immunological aging, namely, the potential relevance of the well-studied human fibroblast replicative senescence model, initially developed by Leonard Hayflick, to cells of the immune system. Extensive research on T cell senescence in cell culture has now documented changes in vitro that closely mirror alterations occurring during in vivo aging in humans, underscoring the biological significance of T cell replicative senescence. Moreover, the inclusion of high proportions of putatively senescent T cells in the 'immune risk phenotype' that is associated with early mortalit...Continue Reading

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Citations

Aug 20, 2010·Journal of Clinical Immunology·Stanley T ParishRita B Effros
Sep 1, 2005·Age·Morris WaskarJohn Tower
May 9, 2006·Antioxidants & Redox Signaling·Giorgio LenazGiancarlo Solaini
Jun 15, 2010·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Nina Friis-MøllerUNKNOWN DAD study group
Dec 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ilhem MessaoudiJanko Nikolich-Zugich
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Luka Cicin-SainJanko Nikolich-Zugich
May 4, 2013·Transplantation Reviews·Timm HeinbokelStefan G Tullius
May 11, 2005·Immunological Reviews·Graham PawelecAnders Wikby
Sep 5, 2006·Immunology Letters·Rania D Kovaiou, Beatrix Grubeck-Loebenstein
Mar 7, 2006·Experimental Gerontology·Christian DejacoMichael Schirmer
Aug 10, 2005·Experimental Gerontology·Janko Nikolich-Zugich, Ilhem Messaoudi
Jan 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tania RescignoAnna Capasso
Jun 23, 2005·The Journal of Pharmacy and Pharmacology·Dominick G A BurtonRichard G A Faragher
Feb 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stanley T ParishRita B Effros
Oct 12, 2017·Frontiers in Genetics·Corinne SidlerIgor Kovalchuk
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stanley T ParishRita B Effros
Jul 6, 2020·Mechanisms of Ageing and Development·Avadh KumarDan Ehninger
May 1, 2021·Genes·Dana LaroccaHal Sternberg

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