From head to toe: Sex and gender differences in the treatment of ischemic cerebral disease

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Lorenzo FalsettiMauro Silvestrini

Abstract

Stroke is a major cause of mortality and morbidity, particularly in the older ages. Women have a longer life expectancy and are more likely to experience stroke than men. Interestingly, the increased risk of ischemic stroke in women seems to be independent from age or classical cardiovascular risk factors. Notwithstanding the fact that stroke outcomes and survival are usually poorer in women, current evidence suggests that thrombolysis, antiplatelet and anticoagulant therapies are more beneficial in women than in men. A possible explanation of this paradox might be that females are often undertreated and they have fewer chances to be submitted to an effective and timely treatment for stroke than the male counterpart. The first step in the attempt to solve this obvious discrimination is surely to emphasize any reasons for differences in the therapeutic approach in relation to gender and then to denounce the lack of a sustainable motivation for them. In this article, we aimed to review the existing literature about gender-related differences on efficacy, administration and side effects of the most common drugs used for the treatment of ischemic stroke. The most striking result was the evidence that the therapeutic approach for st...Continue Reading

References

Jun 27, 2012·Archives of Internal Medicine·Jose GutierrezRalph L Sacco

❮ Previous
Next ❯

Citations

Mar 7, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Danielle BlochDon Weiss
Jul 17, 2018·Endocrinology·Meaghan Roy-O'Reilly, Louise D McCullough
May 17, 2019·Journal of Clinical Microbiology·Claes HenningVolkan Özenci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.