PMID: 11925373Apr 2, 2002Paper

From HMG through purified urinary FSH preparations to recombinant FSH: a substitution study

Human Reproduction
J E F Zwart-van RijkomH G M Leufkens

Abstract

Drugs produced through the use of recombinant DNA techniques have become an integral part of medical practice. Before recombinant FSH (rFSH) was introduced in 1996, FSH purified from the urine of postmenopausal women had been commercially available since the 1960s. We analysed the diffusion and the substitution patterns of the different FSH preparations in The Netherlands. The fact that rFSH preparations have batch-to-batch consistency, are free from urinary protein contaminants and have the potential to be produced in limitless quantities, is advantageous. The question whether newer, more pure FSH products are beneficial from the clinical perspective, has not been settled beyond reasonable doubt. The price of rFSH is three times as high as the price of the former FSH preparations. Due to the introduction of rFSH, total FSH expenditures have grown from 5.0 million Euros in 1995, to 26.8 million Euros in 2000, while the volume increased by <100%. Both the pharmaceutical companies and purchasers (government, insurers) have influenced the patterns of substitution of existing FSH products by biotech equivalents. In general, the risk of increasing pharmaceutical costs without clear clinical benefits has to be set against the risk of...Continue Reading

Citations

Dec 12, 2012·Nature Reviews. Urology·Daniela ValentiAldo E Calogero
Oct 6, 2005·Reproductive Biology and Endocrinology : RB&E·Mohamed F M MitwallyMichael P Diamond
Jun 24, 2010·Reproductive Biomedicine Online·Hesham G Al-Inany, Pieter van Gelder
Jun 15, 2010·Reproductive Biomedicine Online·Jaro Wex-WechowskiRichard Kennedy
Apr 22, 2008·The Urologic Clinics of North America·Howard H Kim, Peter N Schlegel
Feb 21, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Davinia M WhiteStephen Franks
Nov 9, 2018·Expert Opinion on Pharmacotherapy·Ylenia DucaSandro La Vignera
Jul 6, 2019·Asian Journal of Andrology·Rossella CannarellaAldo E Calogero
May 29, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Ylenia DucaUNKNOWN Collaborators (Redox Group Catania)
Jan 8, 2020·Clinical Medicine Insights. Reproductive Health·Shital Sawant, Priya Bhide
Aug 9, 2020·Reproductive Biology and Endocrinology : RB&E·Johan Smitz, Peter Platteau
Jan 24, 2019·Laboratory animal research·M H NooranizadehH Vaseghi

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