PMID: 9534741Apr 16, 1998Paper

From human immunodeficiency virus (HIV) infection of the brain to dementia

Genitourinary Medicine
G Trillo-Pazos, I Everall

Abstract

Human immunodeficiency virus (HIV) can cause both primary and secondary brain diseases. Numerous neuropathological studies have shown that up to 90% of patients with acquired immune deficiency syndrome (AIDS) have lesions in the nervous system. In this review, we discuss the entry of HIV into the brain, the general features of HIV associated neuropathology, the role of different brain cells in HIV mediated neuronal damage, and the putative molecular mechanisms involved. We conclude by correlating which factors might be important in the development of HIV associated dementia.

References

Dec 5, 1992·Lancet·I EverallP Lantos
May 11, 1991·Lancet·I P EverallP L Lantos
Jun 1, 1991·Annals of Neurology·C A WileyR Terry
Oct 1, 1994·Journal of Neuroimmunology·F M HofmanS M Walker
Jan 1, 1994·Advances in Neuroimmunology·T M Dawson, V L Dawson
Apr 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·I P Everall
Mar 1, 1995·Trends in Neurosciences·N J Rothwell, S J Hopkins
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·V L DawsonS H Snyder
Oct 1, 1993·Clinical Microbiology Reviews·W J AtwoodE O Major
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D GiulianC A Noonan
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·H SchmidtmayerovaB Sherry
Apr 10, 1996·AIDS Research and Human Retroviruses·M Di StefanoF Chiodi
Sep 1, 1996·Nature Medicine·G Goldstein
Jan 1, 1996·Annual Review of Neuroscience·J D Glass, R T Johnson
Aug 1, 1996·Trends in Neurosciences·J E Merrill, E N Benveniste
Jan 1, 1996·Brain Pathology·F GrayP Lantos
Jan 1, 1996·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·G Trillo-Pazos, I P Everall
Jan 1, 1996·Journal of Neuro-AIDS·E MasliahC A Wiley

❮ Previous
Next ❯

Citations

Apr 28, 2010·Neuropsychology Review·Sandra ChanraudAdolf Pfefferbaum
Feb 22, 2003·European Journal of Radiology·Edith V Sullivan, Adolf Pfefferbaum
Mar 22, 2014·BMC Infectious Diseases·Paulo AndradeAntónio Sarmento
Oct 19, 2016·Biomaterials Science·Arti VashistMadhavan Nair

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.