From in vitro Experiments to in vivo and Clinical Studies; Pros and Cons

Current Drug Discovery Technologies
Soodabeh SaeidniaMohammad Abdollahi

Abstract

Biomedical investigators use different methods including experimental animals, tissue, and cell cultures as well as computational simulations and clinical studies finding the ways to treat human diseases and disorders. All the mentioned procedures have their own advantages and disadvantages. For instance although animal models provide some drawbacks like difference in biokinetics parameters or extrapolation of results to human, they are more reliable than in vitro tests. The disadvantage of the in vitro procedures is that they are mostly performed on cancerous cell lines that have a substantially abnormal function. Furthermore, although in vitro models are fruitfully used in biological fields, finding an end point, the initial aim of chemical attack, and extrapolation of the effects to the human are some real weaknesses. Absence of biokinetics in in vitro methods may lead to a misinterpretation of the data. The present review has criticized the pros and cons of both methods, especially in the fields of pharmacology, toxicology, and medical sciences.

Citations

Jul 18, 2018·Antimicrobial Agents and Chemotherapy·Amber HowertonErnesto Abel-Santos
Oct 4, 2019·Nature Reviews. Microbiology·Gino VranckenJeroen Raes
Feb 14, 2020·Critical Reviews in Toxicology·Asaad AzarnezhadAmirhossein Ahmadi
Sep 10, 2020·Frontiers in Physiology·Richard BallwegTongli Zhang
Oct 8, 2016·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Nasser Nassiri Koopaei, Mohammad Abdollahi
Sep 13, 2017·Clinical & Experimental Metastasis·Julia A DubowitzBernhard J Riedel
Aug 5, 2020·Probiotics and Antimicrobial Proteins·Ezgi UlkusevenLyndon W Jones
Apr 20, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Sonal SrivastavaSrikanta Kumar Rath
Jan 29, 2019·Clinical Oral Implants Research·Patricia BermejoMariano Sanz
Jan 18, 2017·Expert Opinion on Drug Discovery·Ramin Rezaee, Mohammad Abdollahi
Dec 15, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Bruce A CorlissShayn M Peirce
Jan 13, 2021·Brain Research Bulletin·Zi-Yuan ZhangGuang-Yu Li
Feb 5, 2021·Biology·Nansi López-ValverdeJuan Manuel Ramírez
Jan 15, 2019·Acta Biomaterialia·Ashley N LeberfingerIbrahim T Ozbolat
Mar 18, 2021·Immune Network·Chiranjib ChakrabortySang-Soo Lee
Feb 3, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Konstantinos TsikopoulosDavid Lavalette
May 15, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Lisa BelfioreMartin Engel
May 18, 2021·Ultrasonics·Martin SnehotaHana Kolarova
May 17, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hua GuoHui Zhang
Jun 17, 2021·BMC Microbiology·Qingfeng GeWangang Zhang
Jul 3, 2021·Pharmaceuticals·Hissa F Al-ThaniHuseyin C Yalcin
Jul 22, 2021·Biotechnology and Bioengineering·Nina WichertThomas Scheper
Feb 27, 2021·International Journal of Stem Cells·Jin Yu
Aug 10, 2021·NMR in Biomedicine·Amith Sadananda Maroli, Robert Powers
May 22, 2020·ACS Medicinal Chemistry Letters·Tanya SmitKrzysztof Wrzesinski
Aug 20, 2021·Frontiers in Oncology·Thomas P Wall, Donal J Buggy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

Journal of Steroid Biochemistry
G A Overbeek
AAOHN Journal : Official Journal of the American Association of Occupational Health Nurses
J B Vogler, S Martinez
The Journal of the American Dental Association
C Reitinger
© 2022 Meta ULC. All rights reserved