From intrinsic firing properties to selective neuronal vulnerability in neurodegenerative diseases

Neuron
Francesco Roselli, Pico Caroni

Abstract

Neurodegenerative diseases (NDDs) involve years of gradual preclinical progression. It is widely anticipated that in order to be effective, treatments should target early stages of disease, but we lack conceptual frameworks to identify and treat early manifestations relevant to disease progression. Here we discuss evidence that a focus on physiological features of neuronal subpopulations most vulnerable to NDDs, and how those features are affected in disease, points to signaling pathways controlling excitation in selectively vulnerable neurons, and to mechanisms regulating calcium and energy homeostasis. These hypotheses could be tested in neuronal stress tests involving animal models or patient-derived iPS cells.

References

Jan 1, 1995·Life Sciences·A C Bowling, M F Beal
Feb 18, 2004·The Journal of Clinical Investigation·Vikram G ShakkottaiK George Chandy
Apr 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary D Womack, Kamran Khodakhah
Jul 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bénédicte Salthun-LassallePatrick P Michel
Sep 21, 2004·Nature Reviews. Neuroscience·Martin Stocker
Apr 6, 2005·Trends in Neurosciences·Berislav V Zlokovic
Apr 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew M Swensen, Bruce P Bean
Nov 22, 2005·Nature Neuroscience·Birgit LissJochen Roeper
Apr 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Francesc X SorianoGiles E Hardingham
May 12, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Grace E StutzmannIan Parker
Oct 19, 2006·Pflügers Archiv : European journal of physiology·Olga GaraschukArthur Konnerth
Dec 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Séverine MahonStéphane Charpier
Aug 22, 2007·Neuropharmacology·Yukiori GotoAnthony A Grace
Feb 7, 2008·Nature Reviews. Neuroscience·Serena ZacchignaPeter Carmeliet
Nov 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Catherine M CowanLynn A Raymond
Dec 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pablo E PomataM Gustavo Murer
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Randy L BucknerKeith A Johnson
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Prasad R JoshiNigel S Bamford
Mar 25, 2009·Trends in Neurosciences·C Savio ChanD James Surmeier
Jul 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jian XuPaul J Lombroso
Aug 14, 2009·Journal of Neurophysiology·R C FoehringJ C Callaway
Aug 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Damian M CummingsMichael S Levine
Sep 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jaime N GuzmanD James Surmeier
Oct 21, 2009·Neuron·Maria BjörkqvistSarah J Tabrizi
Nov 4, 2009·Neuromolecular Medicine·Marc Gleichmann, Mark P Mattson
Dec 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah N BlytheMark D Bevan
Dec 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher A DeisterCarlos A Paladini
Jan 8, 2010·Cell Calcium·D James SurmeierJavier Sanchez-Padilla
Apr 7, 2010·Annual Review of Neuroscience·Kevin C KanningChristopher E Henderson
Sep 16, 2010·Nature Reviews. Neuroscience·Giles E Hardingham, Hilmar Bading
Oct 20, 2010·British Journal of Pharmacology·M PotierC Vandier
Nov 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuxiang XieBaoji Xu

❮ Previous
Next ❯

Citations

Oct 31, 2015·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Nov 26, 2015·Neural Regeneration Research·Felix Leroy, Daniel Zytnicki
Apr 14, 2016·Journal of Biological Physics·Elif Kubat ÖktemRobert H Brown
Jul 6, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael J Berridge
Jun 17, 2016·Journal of Neurophysiology·Zhen Yang, Fidel Santamaria
Jun 8, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nicole SilbernagelNiels Decher
Aug 24, 2019·Nature Communications·Victoria García-MoralesBernardo Moreno-López
Jun 3, 2020·The Journal of Experimental Medicine·Marcin BączykDaniel Zytnicki
Jun 28, 2018·Cellular and Molecular Life Sciences : CMLS·Chang Geon ChungSung Bae Lee
Feb 1, 2020·Communications Biology·Weili TianHernán López-Schier
Aug 17, 2018·International Journal of Molecular Sciences·Abraham Rosas-ArellanoMaite A Castro
Jul 10, 2018·Cerebral Cortex·Akila ChandrasekarFrancesco Roselli
Feb 15, 2017·Molecular Neurodegeneration·Michael LattkeBernd Baumann
Sep 27, 2018·Nature Neuroscience·Hongjun FuKaren E Duff
Nov 12, 2020·Critical Reviews in Biochemistry and Molecular Biology·Joshua L SchwartzGene W Yeo
Nov 17, 2020·Frontiers in Molecular Biosciences·Timothy E HoffmanJulie A Moreno
Nov 5, 2020·International Journal of Molecular Sciences·Oliver Wirths, Silvia Zampar
Dec 11, 2020·Brain : a Journal of Neurology·Byeong Eun LeeJae-Ick Kim
Jan 29, 2021·Neuropathology and Applied Neurobiology·Ángela Gento-CaroBernardo Moreno-López
Sep 30, 2021·Brain Pathology·Ángela Gento-CaroBernardo Moreno-López
Jan 20, 2021·CNS & Neurological Disorders Drug Targets·Fatima MaqoudDomenico Tricarico
Dec 24, 2021·Frontiers in Molecular Neuroscience·Victoria García-MoralesBernardo Moreno-López
Dec 27, 2021·Protein Science : a Publication of the Protein Society·Amber L H GrayThanh D Do

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating genetic alterations in this genetically heterogeneous disorder.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

ALS & FTD: TDP-43

TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Related Papers

Western Journal of Nursing Research
J H Flaskerud
Movement Disorders : Official Journal of the Movement Disorder Society
Ryosuke Takahashi, Hodaka Yamakado
© 2022 Meta ULC. All rights reserved