journal cover

From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis

International Journal of Cancer. Journal International Du Cancer

Feb 16, 2016

Sonam Dhamija, Sven Diederichs

Abstract

Metastasis is a multistep process that involves the dissemination of cells from the primary tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a carcinoma acquire an enhanced migratory phenotype in a process called epithelial-to-mesenchymal tra...read more

Mentioned in this Paper

Gene Expression Regulation, Neoplastic
GLI2 protein, human
Genome
RNA, Untranslated
HOTAIR gene
Cell Motility
Squamous Transitional Epithelial Cell Count
MALAT1 long non-coding RNA, human
Primary Neoplasm
Transcription Initiation
8
122
Paper Details
References
  • References145
  • Citations30
12345...
  • References145
  • Citations30
123

Similar Papers Found In These Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Non-Small Cell Lung Cancer Recurrence

Epithelial–Mesenchymal Transition

Epithelial-Mesenchymal Transition is a process where epithelial cells lose their polarity and gain mesenchymal properties, such as increase in cell migration. Discover the latest research on Epithelial-Mesenchymal Transition here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Breast Cancer Cell Invasion

Histones and Splicing (Keystone)

Epigenetic marks on histones can lead to gene expression via transcription or repression. Recently, it was discovered that histone marks not only play a role in gene expression but are also crucial for RNA splicing. Discover the latest research on histones and splicing in this feed.

Cancer Epigenetics Chromatin Complexes (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin complexes and their role in cancer epigenetics.

Mechanisms Of Chromatin Transcription (Keystone)

Studying the mechanisms of gene transcription and its regulation is crucial for understanding regulation of development as well as disease. Follow the latest research relating to Patrick Cramer's talk on "Mechanisms of Chromatin Transcription" with this feed.

lncRNA and PRC2 (Keystone)

Aberrant expression of long noncoding RNAs (lncRNA) has been found to be associated with tumorigenesis and cancer progression. For example, HOTAIR is a lncRNA that interacts with Polycomb repressive complex 2 (PRC2), resulting in regulation of chromatin state and gene silencing. HOTAIR has been found to be over-expressed in breast cancers, due to abnormal gene silencing. Find the latest research on lncRNA, PRC2, and carcinogenesis in this feed.

Cancer Epigenetics and Chromatin (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on chromatin and its role in cancer epigenetics please follow this feed to learn more.

RNA Splicing

The majority of human genes that encode proteins undergo alternative pre-mRNA splicing and mutations that affect splicing are more prevalent than previously thought. Discover the latest research on RNA Splicing here.

Epithelial-Mesenchymal Transition & Cancer

Epithelial-Mesenchymal Transition (EMT) is a process where epithelial cell properties are lost, such as polarity, and mesenchymal cell properties are gained, such as migratory phenotypes. EMT is implicated in cancer progression and the metastatic process. Discover the latest research here.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

RNA Splicing (Keystone)

The majority of human genes that encode proteins undergo alternative pre-mRNA splicing and mutations that affect splicing are more prevalent than previously thought. Discover the latest research on RNA splicing and co-transcriptional splicing in this feed.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Intestinal Parasites & Cancer

Parasitic diseases may affect several hallmarks of cancer. Understanding how these parasites promote oncogenesis will aid in the development of novel treatments for infection-associated malignancy. Discover the latest research on parasites and cancer here.

lncRNA: Stem Cells & Cancer

Long non-coding RNAs (lncRNA) are a class of RNAs that exceed 200 nucleotides in length and cannot be translated into proteins. LncRNAs have been shown to regulate several cellular processes and signaling pathways. Here is the latest research on their role in stem cells and cancer.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Morphogens and Pattern Formation

Morphogens are signaling factors that direct cell fate and tissue development at a distance from their source. They are involved in the establishment of positional information that is essential for pattern formation. Here is the latest research.

Long Non-Coding Rnas

Histones and Splicing

Epigenetic marks on histones can lead to gene expression via transcription or repression. Recently, it was discovered that histones marks not only play a role in gene expression but are also crucial for RNA splicing. Discover the latest research on histones and splicing here.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

lncRNA: Stem Cells & Cancer (Keystone)

Long non-coding RNAs (lncRNA) are a class of RNAs that exceed 200 nucleotides in length and cannot be translated into proteins. LncRNAs have been shown to regulate several cellular processes and signaling pathways. Here is the latest research on their role in stem cells and cancer.

Human Tumor Atlas

The Human Tumor Atlas is a collaborative project that uses detailed maps of a variety of cancers to investigate cancer development, metastasis, and treatments.

Epigenetic Modifications of RNA (Keystone)

Epitranscriptomics is a scientific field that studies epigenetic modifications on RNA. Here is the latest research pertaining to epitranscriptomics and mechanisms that underlie RNA modifications and Dr. Tony Kouzarides keystone talk.

© 2020 Meta ULC. All rights reserved

From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis

International Journal of Cancer. Journal International Du Cancer

Feb 16, 2016

Sonam Dhamija, Sven Diederichs

PMID: 26875870

DOI: 10.1002/ijc.30039

Abstract

Metastasis is a multistep process that involves the dissemination of cells from the primary tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a carcinoma acquire an enhanced migratory phenotype in a process called epithelial-to-mesenchymal tra...read more

Mentioned in this Paper

Gene Expression Regulation, Neoplastic
GLI2 protein, human
Genome
RNA, Untranslated
HOTAIR gene
Cell Motility
Squamous Transitional Epithelial Cell Count
MALAT1 long non-coding RNA, human
Primary Neoplasm
Transcription Initiation
8
122

Similar Papers Found In These Feeds

Paper Details
References
  • References145
  • Citations30
12345...
  • References145
  • Citations30
123
/papers/from-junk-to-master-regulators-of-invasion-lncrna/26875870