Nov 1, 2008

From laboratory science to six emergency medical services systems: New understanding of the physiology of cardiopulmonary resuscitation increases survival rates after cardiac arrest

Critical Care Medicine
Tom P AufderheideKeith G Lurie


The purpose of this study is to: 1) describe a newly mechanism of blood flow to the brain during cardiopulmonary resuscitation using the impedance threshold device in a piglet model of cardiac arrest, and 2) describe the survival benefits in humans of applying all of the highly recommended changes in the 2005 guidelines related to increasing circulation during cardiopulmonary resuscitation, including use of the impedance threshold device, from six emergency medical services systems in the United States. Animal studies prospective trial with each piglet serving as its own control. Historical controls were used for the human studies. Piglets and patients with out-of-hospital cardiac arrest. Piglets (10-12 kg) were treated with an active (n = 9) or sham (n = 9) impedance threshold device after 6 mins of ventricular fibrillation. Humans were treated with cardiopulmonary resuscitation per the American Heart Association 2005 guidelines and the impedance threshold device. The primary endpoint in the piglet study was carotid blood flow which increased from 59 mL/min without an impedance threshold device to 91 mL/min (p = 0.017) with impedance threshold device use. Airway pressures during the chest recoil phase decreased from -0.46 mm H...Continue Reading

  • References30
  • Citations18
  • References30
  • Citations18


Mentioned in this Paper

Coronary Circulation
Ventricular Fibrillation
Ohmic Resistance
Salicylhydroxamic acid
Electric Impedance
Basic Cardiac Life Support
Entire Chest Wall
Hospital Mortality
Blood Flow

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