From lesions to viral clones: biological and molecular diversity amongst autochthonous Brazilian vaccinia virus

Viruses
Graziele OliveiraJônatas S Abrahão

Abstract

Vaccinia virus (VACV) has had an important role for humanity because of its use during the smallpox eradication campaign. VACV is the etiologic agent of the bovine vaccinia (BV), an emerging zoonosis that has been associated with economic, social, veterinary and public health problems, mainly in Brazil and India. Despite the current and historical VACV importance, there is little information about its circulation, prevalence, origins and maintenance in the environment, natural reservoirs and diversity. Brazilian VACV (VACV-BR) are grouped into at least two groups based on genetic and biological diversity: group 1 (G1) and group 2 (G2). In this study, we went to the field and investigated VACV clonal diversity directly from exanthemous lesions, during BV outbreaks. Our results demonstrate that the G1 VACV-BR were more frequently isolated. Furthermore, we were able to co-detect the two variants (G1 and G2) in the same sample. Molecular and biological analysis corroborated previous reports and confirmed the co-circulation of two VACV-BR lineages. The detected G2 clones presented exclusive genetic and biological markers, distinct to reference isolates, including VACV-Western Reserve. Two clones presented a mosaic profile, with both...Continue Reading

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Citations

Apr 9, 2017·Archives of Virology·Galileu Barbosa CostaGiliane de Souza Trindade
Mar 10, 2018·Viruses·Ana Carolina Diniz MatosZélia Inês Portela Lobato
Dec 21, 2017·Emerging Infectious Diseases·Maurício Teixeira LimaErna Geessien Kroon
Oct 2, 2019·Transboundary and Emerging Diseases·João Marcelo Azevedo de Paula AntunesJane Megid
Aug 16, 2016·Current Protocols in Microbiology·Erna Geessien KroonBetânia Paiva Drumond
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Feb 7, 2019·Frontiers in Microbiology·Mauricio Teixeira LimaErna Geessien Kroon
May 19, 2017·Emerging Infectious Diseases·Júlia B MirandaGiliane de S Trindade
Jan 6, 2021·Viruses·Natalia Ingrid Oliveira SilvaBetânia Paiva Drumond
Apr 4, 2021·Pathogens·Iago José da Silva DomingosGiliane de Souza Trindade

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Methods Mentioned

BETA
PCR

Software Mentioned

CLUSTAL
MEGA6
GraphPad Prism
GraphPad
MEGA

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