From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs.

Accounts of Chemical Research
Anne RobertBernard Meunier

Abstract

In the first part of this account, the antimalarial drug artemisinin is presented, and the current hypotheses on the mechanism of action of this endoperoxide-based drug are reviewed. The alkylating ability of artemisinin and synthetic analogues toward heme related to their antimalarial efficacy are underlined. Some possible ways for discovery of new drugs, especially the design of trioxaquines, new active molecules recently patented that have been prepared by covalent attachment of a trioxane residue having alkylating ability to a quinoline moiety known to easily penetrate within infected erythrocytes, are presented.

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Mar 24, 2004·International Journal for Parasitology·Katja BeckerHagai Ginsburg
Mar 20, 2003·Bioorganic & Medicinal Chemistry Letters·Montserrat RodriguezBernard Meunier
Aug 2, 2007·Accounts of Chemical Research·Bernard Meunier
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