From Molecular Biology to Clinical Trials: Toward Personalized Colorectal Cancer Therapy

Clinical Colorectal Cancer
Sabina PalmaEzequiel Lacunza

Abstract

During the past years, molecular studies through high-throughput technologies have led to the confirmation of critical alterations in colorectal cancer (CRC) and the discovery of some new ones, including mutations, DNA methylations, and structural chromosomal changes. These genomic alterations might act in concert to dysregulate specific signaling pathways that normally exert their functions on critical cell phenotypes, including the regulation of cellular metabolism, proliferation, differentiation, and survival. Targeted therapy against key components of altered signaling pathways has allowed an improvement in CRC treatment. However, a significant percentage of patients with CRC and metastatic CRC will not benefit from these targeted therapies and will be restricted to systemic chemotherapy. Mechanisms of resistance have been associated with specific gene alterations. To fully understand the nature and significance of the genetic and epigenetic defects in CRC that might favor a tumor evading a given therapy, much work remains. Therefore, a dynamic link between basic molecular research and preclinical studies, which ultimately constitute the prelude to standardized therapies, is very important to provide better and more effecti...Continue Reading

Citations

Aug 17, 2016·Nanomedicine·Bruno A CisternaCristian Vilos
Sep 28, 2016·Journal of Experimental & Clinical Cancer Research : CR·Run-Wei YangWen-Ting Liao
Dec 14, 2017·Gut·Mark LawlerUNKNOWN Bowel Cancer UK Critical Research Gaps in Colorectal Cancer Initiative
Mar 29, 2019·ANZ Journal of Surgery·Jesse FischerTim W Eglinton
Jul 28, 2019·Biochemical and Biophysical Research Communications·Chang SuYiou Cao
Sep 27, 2020·Cell Death & Disease·An-Cheng QinXing-Sheng Lu

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