From molecules to nanovectors: Current state of the art and applications of photosensitizers in photodynamic therapy.

International Journal of Pharmaceutics
A VergerG Dollo

Abstract

Photodynamic therapy (PDT) is a concept based on a selective activation by light of drugs called photosensitizers (PS) leading to reactive oxygen species production responsible for cell destruction. Mechanisms of photodynamic reaction and cell photo-destruction following direct or indirect mechanisms will be presented as well as PS classification, from first generation molecules developed in the 1960 s to third generation vectorized PS with improved affinity for tumor cells. Many clinical applications in dermatology, ophthalmology, urology, gastroenterology, gynecology, neurosurgery and pneumology reported encouraging results in human tumor management. However, this interesting technique needs improvements that are currently investigated in the field of PS excitation by the design of new PS intended for two-photon excitation or for X-ray excitation. The former excitation technique is allowing better light penetration and preservation of healthy tissues while the latter is combining PDT and radiotherapy so that external light sources are no longer needed to generate the photodynamic effect. Nanotechnology can also improve the PS to reach the tumor cells by grafting addressing molecule and by increasing its aqueous solubility and...Continue Reading

References

Nov 1, 1991·Photochemistry and Photobiology·C S Foote
May 1, 1991·The Australian and New Zealand Journal of Surgery·M D Daniell, J S Hill
Nov 1, 1987·Photochemistry and Photobiology·K AizawaH Kato
Jan 1, 1984·Critical Reviews in Oncology/hematology·T J Dougherty
Jun 1, 1996·Photochemistry and Photobiology·S W YoungR A Miller
May 1, 1997·Journal of Photochemistry and Photobiology. B, Biology·M Ochsner
Jun 24, 1998·Journal of the National Cancer Institute·T J DoughertyQ Peng
Aug 5, 1998·Endoscopy·J MoanJ M Nesland
May 23, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·Z ChenD I Simon
Aug 16, 2002·Lasers in Medical Science·L Brancaleon, H Moseley
Feb 13, 2003·Journal of the American Academy of Dermatology·David M PariserPaul S Yamauchi
Oct 1, 1960·Archives of Dermatology·R L LIPSON, E J BALDES
Jun 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·J MODELL, S SCHWARTZ
Jun 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·J MODELL, S SCHWARTZ
Oct 1, 2003·The European Respiratory Journal·K Moghissi, K Dixon
Jan 7, 2004·Advanced Drug Delivery Reviews·Annelies S L Derycke, Peter A M de Witte
Jun 10, 2005·Journal of Medicinal Chemistry·Claudine ScolaroPaul J Dyson
Jun 2, 2006·Journal of Nanoscience and Nanotechnology·Wei Chen, Jun Zhang
Jun 22, 2006·Lasers in Surgery and Medicine·Masoud Panjehpour, Bergein F Overholt
Jun 24, 2006·Nature Reviews. Cancer·Ana P CastanoMichael R Hamblin
Jul 23, 2008·Technology in Cancer Research & Treatment·Zheng HuangYang K Chen
Jul 26, 2008·Nature Nanotechnology·Wendy R SanhaiMauro Ferrari
May 2, 2009·Journal of Photochemistry and Photobiology. B, Biology·C A RobertsonH Abrahamse
May 21, 2009·Journal of Hepato-biliary-pancreatic Sciences·Fei GaoZhao-Shen Li
Apr 1, 2010·Chemical Reviews·Jonathan P CelliTayyaba Hasan
Jun 17, 2010·Methods in Molecular Biology·David Kessel, Nancy L Oleinick
Oct 12, 2010·Cancer Biology & Therapy·Luciana DiniElisa Panzarini
Mar 2, 2011·Anti-cancer Agents in Medicinal Chemistry·Jonathan F ArambulaJonathan L Sessler
May 28, 2011·CA: a Cancer Journal for Clinicians·Patrizia AgostinisJakub Golab
Dec 23, 2011·Chemical Society Reviews·Dong-Eun LeeIck Chan Kwon
Nov 28, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·C A MortonL R Braathen
Apr 6, 2013·Inorganic Chemistry·Christian PreihsJonathan L Sessler
Mar 13, 2014·Chemical Reviews·Guanying ChenXiaoyuan Chen
Jul 22, 2014·Photochemistry and Photobiology·Mark A Weston, Michael S Patterson
Mar 1, 2005·Photodiagnosis and Photodynamic Therapy·Ana P CastanoMichael R Hamblin
Nov 5, 2014·World Journal of Immunology·Eleonora ReginatoMichael R Hamblin

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Related Papers

Materials Science & Engineering. C, Materials for Biological Applications
Yonghe ZhangXiangdong Kong
International Journal of Molecular Sciences
Manuel Gallardo-VillagránBruno Therrien
© 2021 Meta ULC. All rights reserved