PMID: 8599308Jan 1, 1995Paper

From oxygen content to pulse oximetry: completing the picture in the newborn

Acta Anaesthesiologica Scandinavica. Supplementum
R K WhyteK C Dooley

Abstract

In recent years clinicians caring for sick preterm infants have come to depend on pulse oximetry to avoid hyperoxia, which means assuming saturation values for critical levels of oxygen tension. This prediction is made difficult by the shape of the haemoglobin-oxygen dissociation curve at critical values for arterial pO2 and by the effects of changes in acid-base balance on p50. Combined blood gas and co-oximetry measurements can be used to determine critical limits for pulse oximetry. Fetal haemoglobin has slightly different light absorption characteristics from adult haemoglobin. To adjust for this, adult and fetal matrices are available in the OSM 3 HEMOXIMETER (Radiometer Medical A/S, Denmark) but the measurement requires an extra preliminary step to estimate fetal haemoglobin concentration. We sought to determine the importance of this extra procedure for measuring the saturation of newborn blood, and to determine whether the adult or fetal mode should be used for determining saturation for comparison with pulse oximeters. We measured the effect of the correction for fetal haemoglobin by obtaining absorbances from the co-oximeter and multiplying them by the adult and fetal matrices. We demonstrated that, at 90% saturation,...Continue Reading

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Citations

Sep 17, 2013·Seminars in Fetal & Neonatal Medicine·Yacov Rabi, Jennifer A Dawson
Nov 26, 2015·Clinics in Perinatology·Brian A Darlow, Colin J Morley
Nov 18, 2005·The Journal of Perinatal & Neonatal Nursing·Shyang-Yun Pamela K Shiao
Dec 29, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D J Anderson
Jun 9, 2007·Annals of Neurology·Daniel J BonthiusPaul D Larsen

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