From paramutation to human disease: RNA-mediated heredity

Seminars in Cell & Developmental Biology
Minoo Rassoulzadegan, François Cuzin

Abstract

Epigenetic variation, a stable alteration in gene expression, occurs at multiple moments during development. Several instances of non-Mendelian transmission to the progenies modes are very intriguing. Studies of the mode of hereditary transmission revealed in a series of such cases a role of noncoding RNA molecules as inducers. While still an enigmatic mechanism, emerging models pinpoint to a more general roles of these variations, initiated as a response to genetic and environmental variation. Here we compare the known modes of transgenerational epigenetic variation in mice and humans.

References

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Citations

Nov 12, 2016·The Journal of Pediatrics·Emily W HarvilleLydia A Bazzano
Apr 28, 2017·Scientific Reports·Jean GoldingMarcus Pembrey
Mar 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paola MirraFrancesco Beguinot
Apr 20, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Dragan Stajic, Lars E T Jansen

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