From percept to concept in the ventral temporal lobes: Graded hemispheric specialisation based on stimulus and task

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Paul Hoffman, Matthew A Lambon Ralph

Abstract

The left and right ventral anterior temporal lobes (vATL) have been implicated as key regions for the representation of conceptual knowledge. However, the nature and degree of hemispheric specialisation in their function is unclear. To address this issue, we investigated hemispheric specialisation in the ventral temporal lobes using a distortion-corrected spin-echo fMRI protocol that enhanced signal in vATL. We employed an orthogonal manipulation of stimulus (written words vs pictured objects) and task (naming vs recognition). Words elicited left-lateralised vATL activation while objects elicited bilateral activation with no hemispheric bias. In contrast, posterior ventral temporal cortex exhibited a rightward bias for objects as well as a leftward bias for words. Naming tasks produced left-lateralised activation in vATL while activity for recognition was equal in left and right vATLs. These findings are incompatible with proposals that left and right ATLs are strongly modular in function, since these predict rightward as well as leftward biases. Instead, they support an alternative model in which (a) left and right ATL together form a bilateral, integrated system for the representation of concepts and (b) within this system, g...Continue Reading

Citations

May 7, 2019·Journal of Neuropsychology·Yasser Alemán-GómezPablo Campo
Jan 27, 2020·Neuroscience and Biobehavioral Reviews·Richard J Binney, Richard Ramsey
Nov 24, 2020·Brain Communications·Tobias PflugshauptThomas Nyffeler
May 13, 2021·Nature Communications·Adam SteelCaroline E Robertson
Aug 11, 2020·Neuropsychologia·Angélique VolfartHélène Brissart

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Software Mentioned

Eprime
vATL
FIACH
SPM12
Marsbar
DARTEL

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