From plant extract to molecular panacea: a commentary on Stone (1763) 'An account of the success of the bark of the willow in the cure of the agues'

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
John N Wood

Abstract

The application of aspirin-like drugs in modern medicine is very broad, encompassing the treatment of inflammation, pain and a variety of cardiovascular conditions. Although anecdotal accounts of willow bark extract as an anti-inflammatory drug have occurred since written records began (for example by Hippocrates), the first convincing demonstration of a potent anti-pyretic effect of willow bark containing salicylates was made by the English cleric Edward Stone in the late eighteenth century. Here, we discuss the route to optimizing and understanding the mechanism of action of anti-inflammatory drugs that have their origins in Stone's seminal study, 'An account of the success of the bark of the willow in the cure of agues'. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.

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Citations

Mar 13, 2016·International Immunopharmacology·James E Talmadge
Mar 10, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Robin A Weiss, José Esparza
Jul 4, 2016·The Science of the Total Environment·Andreas SchaefferMartina Roß-Nickoll
Jan 21, 2017·British Journal of Haematology·Michael J R Desborough, David M Keeling
Aug 13, 2017·The Veterinary Record·P LeesM L Whitehead
Jun 5, 2019·The Journal of Animal Ecology·Emily G SimmondsBen C Sheldon
May 29, 2019·The American Journal of Bioethics : AJOB·Jake Earl
Nov 2, 2019·European Journal of Pharmacology·Jolanta HybiakElżbieta Urasińska
Aug 14, 2021·Ageing Research Reviews·Dorit Samocha-BonetDavid K Ryugo
Sep 14, 2021·Annual Review of Pharmacology and Toxicology·Kaitlyn E Redford, Geoffrey W Abbott

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