From plateau to pseudo-plateau bursting: making the transition.

Bulletin of Mathematical Biology
Wondimu TekaJoël Tabak

Abstract

Bursting electrical activity is ubiquitous in excitable cells such as neurons and many endocrine cells. The technique of fast/slow analysis, which takes advantage of time scale differences, is typically used to analyze the dynamics of bursting in mathematical models. Two classes of bursting oscillations that have been identified with this technique, plateau and pseudo-plateau bursting, are often observed in neurons and endocrine cells, respectively. These two types of bursting have very different properties and likely serve different functions. This latter point is supported by the divergent expression of the bursting patterns into different cell types, and raises the question of whether it is even possible for a model for one type of cell to produce bursting of the type seen in the other type without large changes to the model. Using fast/slow analysis, we show here that this is possible, and we provide a procedure for achieving this transition. This suggests that the design principles for bursting in endocrine cells are just quantitative variations of those for bursting in neurons.

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Citations

Jan 24, 2012·Journal of Mathematical Neuroscience·Wondimu TekaRichard Bertram
Jun 5, 2012·Journal of Mathematical Neuroscience·John BurkeMark A Kramer
Sep 18, 2012·Discrete and Continuous Dynamical Systems. Series a·Hinke M OsingaKrasimira Tsaneva-Atanasova
Jul 4, 2013·Journal of Computational Neuroscience·Theodore VoMartin Wechselberger
Nov 1, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Lei WangYanjun Zeng
May 3, 2020·Chaos·Yangyang Wang, Jonathan E Rubin

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