From reactive arthritis to rheumatoid arthritis

Journal of Autoimmunity
P Toivanen

Abstract

Reactive arthritis was initially described as a sterile synovitis, without microbial components present in the joint tissue. It has, however, become evident that bacterial degradation products, and even bacterial DNA, are present in the synovium of patients with this disease. Since intestinal pathogens are important causes of reactive arthritis, and since cellular homing allows transport of bacterial products from the gut to synovium, we have approached the etiology of rheumatoid arthritis from this point of view. A series of observations has led to a hypothesis that patients with rheumatoid arthritis might favour, for genetic reasons, intestinal bacteria which are capable of inducing arthritis. In the long-run, with continuous seeding of bacterial products from the gut, the synovial inflammation is followed by erosion, exposition of cartilage antigens, and autoimmunity.

References

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Citations

Jul 6, 2001·Scandinavian Journal of Immunology·X ZhangP Toivanen
Apr 16, 2004·Clinical Microbiology Reviews·Inés ColmegnaLuis R Espinoza
May 14, 2004·Annals of the Rheumatic Diseases·J R KirwanF Van den Bosch
Nov 25, 2003·Scandinavian Journal of Rheumatology·K HatakkaR Korpela
Jul 17, 2012·The Medical Clinics of North America·Anthony Tam, Don D Sin
Jun 16, 2009·Revue de pneumologie clinique·M El BaajM Kabiri
Aug 12, 2004·Respiratory Medicine·D E SimcockN S T Gendi
Feb 24, 2006·Nutrition Reviews·Janine Ezendam, Henk van Loveren
Oct 12, 2004·Inflammatory Bowel Diseases·Robin L Jump, Alan D Levine
Aug 21, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Francesca PolverinoCaroline A Owen
May 31, 2003·Nature Reviews. Drug Discovery·Josef S Smolen, Günter Steiner
Jan 6, 2018·Inflammopharmacology·Seyed Mohammad Aqaeinezhad RudbaneSeyed Mohammad Mazloomi

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