From rodent glial precursor cell to human glial neoplasia in the oligodendrocyte-type-2 astrocyte lineage

Glia
M NobleS Williams

Abstract

With only a few exceptions, the precursor cells representing the normal counterparts of human tumours are unknown. The comparative lack of information about the lineages involved in tissue development, and difficulties in growing many human tumors in a manner suitable for cellular biological analysis, together often make it difficult to study the differences between normal and tumor cells and to develop many of the model systems that would be useful in the study of human cancer. By applying techniques previously utilized to study glial progenitor cells, we have isolated a human glioblastoma multiforme (GBM)-derived population that expresses many properties otherwise uniquely expressed by oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells. Hu-O-2A/Gb1 (for Human O-2A lineage Glioblastoma number 1) cells responded to similar mitogens and differentiation modulators as rodent O-2A progenitors, and generated cells with features of precursor cells, oligodendrocytes and astrocytes. Moreover, 1H-NMR analysis of amino acid composition demonstrated a striking conversation of types and quantities of free amino acids between the human tumour cells and the rodent primary cells. Hu-O-2A/Gb1 cells represent the first human glioma-derive...Continue Reading

References

Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P S JatD Kioussis
Apr 1, 1991·Current Opinion in Cell Biology·A K GrovesM Noble
Jan 1, 1992·The Journal of Cell Biology·D WrenM Noble
Jan 1, 1991·Annals of the New York Academy of Sciences·B P FultonM C Raff
Jan 1, 1991·Annals of the New York Academy of Sciences·O Bögler, M Noble
Apr 1, 1991·Journal of Neuroscience Research·S F Hunter, J E Bottenstein
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·O BöglerM Noble
May 1, 1990·Annals of Neurology·D R MacdonaldJ G Cairncross
Jan 1, 1987·Acta Neuropathologica·R D Davenport, P E McKeever
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R P Saneto, J de Vellis
Sep 1, 1987·Neuropathology and Applied Neurobiology·P G KennedyM D Noble
Apr 1, 1988·Annals of Neurology·J G Cairncross, D R Macdonald
Aug 1, 1985·Brain Research·P A Eccleston, D H Silberberg
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·M C RaffM Noble
Mar 1, 1995·Trends in Neurosciences·R J Franklin, W F Blakemore
Jan 1, 1995·Journal of Neuropathology and Experimental Neurology·J A KrausA von Deimling
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·Z IkramP S Jat
Jan 1, 1994·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·A von DeimlingO D Wiestler
Jan 1, 1993·Acta Neuropathologica·A von DeimlingB R Seizinger
Jan 1, 1993·Brain Pathology·A von DeimlingD N Louis

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Citations

Apr 15, 2004·Molecular and Cellular Neurosciences·Raghuram SelvarajuUrsula Boschert
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y ShoshanS M Staugaitis
Jul 11, 2001·Advances in Anatomic Pathology·A Perry
Apr 3, 2001·Annual Review of Neuroscience·R Wechsler-Reya, M P Scott
Oct 25, 2008·BMC Developmental Biology·James T CampanelliYing Liu
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·Q R LuP M Black
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M S RaoM Mayer-Pröschel
Sep 24, 2013·Human Pathology·Takanori HiroseAtsushi Sasaki
Nov 22, 2007·Neoplasia : an International Journal for Oncology Research·Per Ø SakariassenMartha Chekenya
Jan 1, 1997·Molecular and Cellular Neurosciences·T D PalmerF H Gage
Feb 26, 2003·The Journal of Biological Chemistry·Patricia A RitchHarald Sontheimer
Dec 22, 1998·NMR in Biomedicine·J D Bell, K K Bhakoo
Nov 15, 2002·Journal of Neuropathology and Experimental Neurology·Arie PerryJohan M Kros
Jun 17, 2004·Journal of Neuropathology and Experimental Neurology·Keith L LigonDavid H Rowitch
Mar 3, 2004·Journal of Neuropathology and Experimental Neurology·Biagio AzzarelliRuben Vidal
Feb 21, 2002·Journal of Neuropathology and Experimental Neurology·Marius Wernig, Oliver Brüstle
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Loukas G AstrakasPeter McLaren Black
Jan 12, 2021·Therapeutic Advances in Medical Oncology·Pragya GuptaPeter J Wookey

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