From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer.

The Journal of Pathology
Anna V LapukColin C Collins

Abstract

The current paradigm of cancer care relies on predictive nomograms which integrate detailed histopathology with clinical data. However, when predictions fail, the consequences for patients are often catastrophic, especially in prostate cancer where nomograms influence the decision to therapeutically intervene. We hypothesized that the high dimensional data afforded by massively parallel sequencing (MPS) is not only capable of providing biological insights, but may aid molecular pathology of prostate tumours. We assembled a cohort of six patients with high-risk disease, and performed deep RNA and shallow DNA sequencing in primary tumours and matched metastases where available. Our analysis identified copy number abnormalities, accurately profiled gene expression levels, and detected both differential splicing and expressed fusion genes. We revealed occult and potentially dormant metastases, unambiguously supporting the patients' clinical history, and implicated the REST transcriptional complex in the development of neuroendocrine prostate cancer, validating this finding in a large independent cohort. We massively expand on the number of novel fusion genes described in prostate cancer; provide fresh evidence for the growing link ...Continue Reading

References

May 30, 1998·Journal of the National Cancer Institute·M W KattanP T Scardino
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M W KattanP T Scardino
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Markus GraefenMichael W Kattan
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mohamed-Ali HakimiRamin Shiekhattar
Aug 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Markus GraefenMichael W Kattan
Apr 16, 2003·The Journal of Cell Biology·Huaye ZhangAlan F Horwitz
Sep 6, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N PavlidisF A Greco
May 13, 2004·Human Molecular Genetics·Pamela L ParisHerman van Dekken
Jan 22, 2005·European Urology·Nadezda Vashchenko, Per-Anders Abrahamsson
Aug 18, 2005·Journal of the National Cancer Institute·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Mar 21, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Julian P Venables
Apr 28, 2006·Nature Genetics·Michael ReichJill P Mesirov
Jun 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vincenzo PagliaruloRichard J Cote
Feb 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dragan MaricJeffery L Barker
Jun 19, 2007·Nature Reviews. Genetics·Lezanne Ooi, Ian C Wood
Jul 20, 2007·Oncogene·G AttardUNKNOWN Transatlantic Prostate Group
Oct 25, 2007·Nature Reviews. Cancer·Julio A Aguirre-Ghiso
Feb 20, 2008·Neoplasia : an International Journal for Oncology Research·Scott A TomlinsArul M Chinnaiyan
Apr 28, 2009·Biochemical and Biophysical Research Communications·Sojoong ChoiJae Youn Yi
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri, Robert A Weinberg
Jun 23, 2009·Genome Research·Martin KrzywinskiMarco A Marra
Aug 7, 2009·Nature Reviews. Urology·Jeremy P Clark, Colin S Cooper
Sep 30, 2009·Prostate Cancer and Prostatic Diseases·A PopovićD Tomas
Nov 3, 2009·Nature Biotechnology·Xiao-Song WangArul M Chinnaiyan
Nov 19, 2009·Nucleic Acids Research·Robert D FinnAlex Bateman
Jan 14, 2010·Molecular Cancer Research : MCR·Amina ZoubeidiMartin E Gleave
Apr 8, 2010·Science Translational Medicine·Rebecca J LearyVictor E Velculescu
Jun 22, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Samson W FineVictor E Reuter
Jun 29, 2010·Cancer Cell·Barry S TaylorWilliam L Gerald
Jul 8, 2010·Molecular Cancer Research : MCR·Anna LapukJoe W Gray
Jul 21, 2010·The Journal of Clinical Investigation·Shihua SunStephen R Plymate
Aug 10, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yohei MiyagiEiju Tsuchiya
Sep 9, 2010·Proceedings of the National Academy of Sciences of the United States of America·Philip A WatsonCharles L Sawyers
Sep 14, 2010·Nature Methods·Malachi GriffithMarco A Marra
Oct 16, 2010·The Prostate·Wei-Lin TungYuzhuo Wang
Feb 11, 2011·Nature·Michael F BergerLevi A Garraway
Feb 12, 2011·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Radoje Drmanac
Feb 26, 2011·Nature·Jose M C Tubio, Xavier Estivill
Mar 26, 2011·The Journal of Clinical Investigation·Yusuke ShiozawaRussell S Taichman

❮ Previous
Next ❯

Citations

Mar 19, 2013·Asian Journal of Andrology·Zhen LiJiaoti Huang
Oct 29, 2013·Nucleic Acids Research·Charlotte SvenssonAmilcar Flores-Morales
Mar 5, 2014·Asian Journal of Andrology·Julia LipianskayaJiaoti Huang
May 17, 2014·Asian Journal of Andrology·Anna V LapukColin C Collins
Feb 19, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Brittany KlebAna Aparicio
Aug 27, 2014·Genome Biology·Alexander W WyattColin C Collins
Jul 16, 2013·Science China. Life Sciences·Yang ZongJiaoti Huang
Oct 13, 2015·International Journal of Cancer. Journal International Du Cancer·Agata RodeAurélie Ernst
Jun 8, 2013·The Journal of Pathology·Alexander W Wyatt, Colin C Collins
Sep 4, 2013·Genes, Chromosomes & Cancer·Juan-Miguel MosqueraCristina R Antonescu
Aug 29, 2012·Genes, Chromosomes & Cancer·Chunxiao WuColin C Collins
Aug 21, 2014·International Journal of Cancer. Journal International Du Cancer·Ning XieXuesen Dong
Jun 16, 2015·Lancet·Gerhardt AttardJohann S de Bono
May 3, 2015·Endocrine-related Cancer·Jennifer L BishopAmina Zoubeidi
Jun 14, 2013·Cell Cycle·Carlos Oscar Sánchez SorzanoKarel H M van Wely
Nov 17, 2012·Developmental Cell·Mathew J K Jones, Prasad V Jallepalli
Feb 24, 2015·Frontiers in Oncology·Panagiotis J Vlachostergios, Christos N Papandreou
Jan 13, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kohei HashimotoNaoya Masumori
Apr 12, 2014·Frontiers in Oncology·Stéphane Terry, Himisha Beltran
Jun 27, 2014·Frontiers in Genetics·Josée Guirouilh-BarbatBernard S Lopez
Jul 13, 2016·Genes, Chromosomes & Cancer·Thale Kristin OlsenPetter Brandal
Aug 5, 2016·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Mercedes Salido, Jose Vilches
Jul 20, 2016·Cancer Biomarkers : Section a of Disease Markers·Bing YangXiang Chen
Aug 19, 2016·Expert Review of Anticancer Therapy·M Francesca Monn, Liang Cheng
Nov 23, 2016·Nature Reviews. Clinical Oncology·Guilhem RoubaudDavid J Mulholland
Sep 17, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott T Tagawa
Apr 1, 2017·Current Oncology Reports·Panagiotis J VlachostergiosHimisha Beltran
Jun 7, 2017·Nature Medicine·David S RickmanMark A Rubin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.