From simultaneous to synergistic MR-PET brain imaging: A review of hybrid MR-PET imaging methodologies

Human Brain Mapping
Zhaolin ChenGary F Egan

Abstract

Simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) scanning is a recent major development in biomedical imaging. The full integration of the PET detector ring and electronics within the MR system has been a technologically challenging design to develop but provides capacity for simultaneous imaging and the potential for new diagnostic and research capability. This article reviews state-of-the-art MR-PET hardware and software, and discusses future developments focusing on neuroimaging methodologies for MR-PET scanning. We particularly focus on the methodologies that lead to an improved synergy between MRI and PET, including optimal data acquisition, PET attenuation and motion correction, and joint image reconstruction and processing methods based on the underlying complementary and mutual information. We further review the current and potential future applications of simultaneous MR-PET in both systems neuroscience and clinical neuroimaging research. We demonstrate a simultaneous data acquisition protocol to highlight new applications of MR-PET neuroimaging research studies.

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Citations

Jan 4, 2019·Human Brain Mapping·Zhaolin ChenGary F Egan
Jun 11, 2020·Current Opinion in Neurology·Nadya PyatigorskayaLaura Rozenblum
Dec 20, 2019·Science Translational Medicine·Mukesh G HarisinghaniRalph Weissleder
Jul 14, 2020·Current Opinion in Neurology·Nadya PyatigorskayaLaura Rozenblum
May 13, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Andrii PozarukGary Egan
Oct 1, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Antoine Verger, Eric Guedj
Oct 23, 2020·Scientific Data·Sharna D JamadarGary F Egan
Feb 16, 2021·Journal of Magnetic Resonance Imaging : JMRI·Anjan BhattaraiZhaolin Chen
Mar 13, 2020·NeuroImage·Shenpeng LiZhaolin Chen
Nov 16, 2018·ACS Medicinal Chemistry Letters·Allen F BrooksMichael R Kilbourn
Mar 22, 2022·European Journal of Nuclear Medicine and Molecular Imaging·Cameron Dennis PainZhaolin Chen
Nov 18, 2021·The Journal of Clinical Endocrinology and Metabolism·Chris MoranVelandai Srikanth

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