From single gene analysis to single cell profiling: a new era for precision medicine

Journal of Experimental & Clinical Cancer Research : CR
Maria Teresa Di MartinoMichele Caraglia

Abstract

Molecular profiling of DNA and RNA has provided valuable new insights into the genetic basis of non-malignant and malignant disorders, as well as an increased understanding of basic mechanisms that regulate human disease. Recent technological advances have enabled the analyses of alterations in gene-based structure or function in a comprehensive, high-throughput fashion showing that each tumor type typically exhibits distinct constellations of genetic alterations targeting one or more key cellular pathways that regulate cell growth and proliferation, evasion of the immune system, and other aspects of cancer behavior. These advances have important implications for future research and clinical practice in areas as molecular diagnostics, the implementation of gene or pathway-directed targeted therapy, and the use of such information to drive drug discovery. The 1st international and 32nd Annual Conference of Italian Association of Cell Cultures (AICC) conference wanted to offer the opportunity to match technological solutions and clinical needs in the era of precision medicine.

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Citations

Oct 30, 2020·Journal of Experimental & Clinical Cancer Research : CR·Claudio LuchiniAldo Scarpa
Aug 28, 2021·Biomolecules·Cian D'Arcy, Christina Kiel

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Methods Mentioned

BETA
genotyping
biopsies
biopsy
Smart-seq-2
RNAseq
gene panel
chips

Software Mentioned

Linkage Explorer
DECO
Linkage Analyzer

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