From skin allograft coverage to allograft-micrograft sandwich method: A retrospective review of severe burn patients who received conjunctive application of cultured epithelial autografts

Burns : Journal of the International Society for Burn Injuries
Alvin Wen Choong ChuaSi Jack Chong

Abstract

A 12-year retrospective review of severe burn patients who received cultured epithelial autografts (CEA) at the Singapore General Hospital Burns Centre from January 2005 to December 2016 was carried out. During this period, two different surgical modalities were employed to manage these burn injuries. In the earlier period, following early excision of the burn wounds, exposed surfaces were covered with a combination of split thickness skin autografts (STSG) and allografts. Surfaces covered with skin allografts were subsequently debrided of the allo-epidermis in about 3 weeks later, exposing the allodermis with granulating tissues for grafting of CEA; a technique known as the Cuono's method. In the later period, allograft-autologous micrograft sandwich technique was used to graft on the early excised burns with subsequent CEA grafting. The former and latter groups represented by STSG/C (n=10) and M/CEA (n=14) respectively, were compared in terms of clinical profiles, outcomes, allograft/CEA usage and total graft cost. No significant differences were found based on mean age and presence of inhalation burns between the two treatment methods However, percentage total body surface area (TBSA) and Revised Baux Score were significantl...Continue Reading

Citations

Jul 25, 2018·Stem Cells and Development·Brice MagneMarina Trouillas
May 9, 2019·Journal of Tissue Engineering and Regenerative Medicine·Maia M AlexalineMarina Trouillas
Feb 7, 2020·Annals of Plastic Surgery·Chunyang WangWilliam C Lineaweaver
Dec 13, 2019·Advances in Wound Care·Thomas Charles LangChristopher John Jackson
May 23, 2020·Plastic and Reconstructive Surgery. Global Open·Kensaku HishidaHideto Watanabe
Dec 21, 2018·Advances in Skin & Wound Care·Michael H E Hermans
Jan 27, 2021·Journal of Clinical Medicine·Anna Paulina Domaszewska-SzostekMaria Siemionow
Jan 19, 2021·ACS Biomaterials Science & Engineering·Irene Anton-SalesAnna Roig

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