From spermatocytes to sperm: meiotic behaviour of human male reciprocal translocations

Human Reproduction
M Oliver-BonetJ Benet

Abstract

Human male translocation carriers may present alterations in the meiotic process due to the presence of the translocated chromosomes. The aim of this work was to study the mechanisms that affect meiotic segregation in translocation carriers by analysing different stages of the meiotic process. Meiotic studies using fluorescence in-situ hybridization on both spermatocytes and sperm nuclei were performed in two translocation carriers, t(11;17)(q13.1;p11.2) and t(10;14)(q24;q32). A ring configuration was the main type of quadrivalent found in metaphase I. Overall chiasma frequency was significantly decreased in the t(11;17) carrier. In the t(10;14) carrier, chiasma frequency within the interstitial region of chromosomes 10 and 14 was increased and the recombination pattern was modified. As expected from the frequencies of interstitial chiasmata found in metaphase I in the two subjects, the incidence of asymmetric dyads was sporadic in t(11;17) and very high in t(10;14). In both carriers, segregation frequencies observed at metaphase II were not different from the segregation data obtained in decondensed sperm nuclei. The concordance observed among results obtained in different spermatogenic stages indicates an absence of cellular ...Continue Reading

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Citations

Jun 7, 2008·Human Reproduction Update·R H Martin
Sep 30, 2005·Cytogenetic and Genome Research·C TempladoJ Benet
Sep 30, 2005·Cytogenetic and Genome Research·J BenetJ Navarro
May 8, 2007·Fertility and Sterility·Nadja GneistWolfgang Distler
Aug 19, 2008·Fertility and Sterility·Aurore PerrinFrédéric Morel
Feb 6, 2007·Fertility and Sterility·Anna KékesiAndrás Tóth
Aug 10, 2005·Prenatal Diagnosis·Isabel Lorda-SánchezCarmen Ramos
Apr 6, 2006·American Journal of Medical Genetics. Part a·Tahsin YakutUnal Egeli
Sep 18, 2008·American Journal of Medical Genetics. Part a·Aziza LebbarJean-Michel Dupont
Nov 23, 2005·International Journal of Andrology·N Douet-GuilbertF Morel
Dec 7, 2013·Biological Journal of the Linnean Society·D M SoperC M Lively
Sep 23, 2016·Journal of Assisted Reproduction and Genetics·Mireia SoléZaida Sarrate
May 17, 2005·Prenatal Diagnosis
Dec 20, 2019·Current Sexual Health Reports·Samantha L P Schilit

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