From systems biology to metabolically engineered cells-an omics perspective on the development of industrial microbes

Current Opinion in Microbiology
Judith Becker, Christoph Wittmann

Abstract

Green routes are indispensable for a sustainable production of energy, chemicals and materials, and health and nutrition products from renewable resources. Naturally, microbes are capable to conduct many of the desired biochemical conversions involved, however, only at rather low efficiency. It is therefore essential to metabolically engineer them towards efficient cell factories, which enable a high product titer, yield and productivity, exhibit a good process robustness and a broad substrate spectrum, and are safe to be used, to name a few prominent points from the wish list for industrial bio-production. Such optimization of a microbial cell typically involves the implementation of several up to multiple traits into its genome, which then mediate the desired phenotype. While the genetic modification step itself is straightforward due to the much advanced genome editing methods, the selection of what exactly has to be optimized out of the manifold possibilities is still a challenge. Here we will discuss, how systems biology can offer guidance to orchestrate the hundreds to thousands of biochemical conversions of a microbe into a concert of desired performance. To this end, we will highlight recent success stories, where syste...Continue Reading

Citations

May 10, 2019·Biotechnology Journal·Lorena Fernández-CabezónPablo I Nikel
Jul 23, 2019·Critical Reviews in Biotechnology·Ayodeji AmobonyeSanthosh Pillai
Dec 10, 2019·Biotechnology and Bioengineering·Guan WangSiliang Zhang
Mar 19, 2019·Microbial Biotechnology·Ignacio Poblete-CastroPablo I Nikel
Aug 28, 2019·Natural Product Reports·Maksym Myronovskyi, Andriy Luzhetskyy
Apr 27, 2019·Frontiers in Microbiology·Peter C St John, Yannick J Bomble
Jul 20, 2019·Microbial Cell Factories·Shuhei NodaTomokazu Shirai
Aug 23, 2019·Biotechnology Advances·Luísa Czamanski NoraRafael Silva-Rocha
Mar 22, 2020·Current Opinion in Biotechnology·Judith Becker, Christoph Wittmann
May 4, 2021·Frontiers in Microbiology·Xinyi ChenHu Liu
May 28, 2021·Applied Microbiology and Biotechnology·Noora BarzkarMojgan Khodadadi
Jul 25, 2021·Biotechnology Advances·Charlotte RouxLaurence Girbal
Jul 9, 2021·Applied Microbiology and Biotechnology·Nidhi Y PatelVikram H Raval
Nov 13, 2020·ACS Synthetic Biology·Anne Sofie Lærke HansenMichael K Jensen

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