From systems biology to photosynthesis and whole-plant physiology: a conceptual model for integrating multi-scale networks.

Plant Signaling & Behavior
David J WestonStan D Wullschleger

Abstract

Network analysis is now a common statistical tool for molecular biologists. Network algorithms are readily used to model gene, protein and metabolic correlations providing insight into pathways driving biological phenomenon. One output from such an analysis is a candidate gene list that can be responsible, in part, for the biological process of interest. The question remains, however, as to whether molecular network analysis can be used to inform process models at higher levels of biological organization. In our previous work, transcriptional networks derived from three plant species were constructed, interrogated for orthology and then correlated with photosynthetic inhibition at elevated temperature. One unique aspect of that study was the link from co-expression networks to net photosynthesis. In this addendum, we propose a conceptual model where traditional network analysis can be linked to whole-plant models thereby informing predictions on key processes such as photosynthesis, nutrient uptake and assimilation, and C partitioning.

References

Feb 7, 2006·Current Opinion in Plant Biology·Hans J BohnertShisong Ma
Mar 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marieke van HultenJurriaan Ton
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Bin Zhang, Steve Horvath
Jun 6, 2007·BMC Systems Biology·Jun Dong, Steve Horvath
Aug 22, 2008·The New Phytologist·Malcolm Bennett, Nick Monk
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Bas TeusinkFrank J Bruggeman
Feb 12, 2011·Plant, Cell & Environment·Mikaël LucasMalcolm J Bennett

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Citations

Oct 27, 2012·Tree Physiology·Stan D WullschlegerG A Tuskan
Mar 29, 2014·Planta·Bhavisha P Sheth, Vrinda S Thaker
Feb 19, 2013·Plant Science : an International Journal of Experimental Plant Biology·Alessandra Salvioli, Paola Bonfante
Aug 18, 2018·The Plant Journal : for Cell and Molecular Biology·Miroslava RakocevicRenata Fuganti-Pagliarini
Jun 28, 2018·Theory in Biosciences = Theorie in Den Biowissenschaften·Ulrich Kutschera

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