From T to B and back again: positive feedback in systemic autoimmune disease

Nature Reviews. Immunology
Mark J ShlomchikM J Mamula

Abstract

Systemic lupus erythematosus, a prototypical systemic autoimmune disease, is the result of a series of interactions within the immune system that ultimately lead to the loss of self-tolerance to nuclear autoantigens. Here, we present an integrated model that explains how self-tolerance is initially lost and how the loss of tolerance is then amplified and maintained as a chronic autoimmune state. Key to this model are the self-reinforcing interactions of T and B cells, which we suggest lead to perpetuation of autoimmunity as well as its spread to multiple autoantigen targets.

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References

Oct 1, 1992·The Journal of Experimental Medicine·T ZhouJ D Mountz
Feb 1, 1991·The Journal of Experimental Medicine·E Roosnek, A Lanzavecchia
Jan 1, 1992·The Journal of Experimental Medicine·M OkamotoT Honjo
Jun 11, 1991·The Journal of Experimental Medicine·R H LinC A Janeway
Jan 1, 1990·Kidney International·E AlexopoulosJ S Cameron
Jan 1, 1990·The Journal of Experimental Medicine·M ShlomchikM Weigert
Dec 1, 1989·The Journal of Experimental Medicine·P A SingerA N Theofilopoulos
Oct 1, 1987·Laboratory Animals·M Hewicker, G Trautwein
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J D CongerG J Nossal
Aug 2, 1987·Nature·M J ShlomchikM G Weigert
Sep 1, 1987·The Journal of Clinical Investigation·R A EisenbergP L Cohen
Nov 1, 1985·Archives of Internal Medicine·J R O'DellJ C Steigerwald
Apr 1, 1995·The Journal of Experimental Medicine·A RosenJ Ahearn
Jan 28, 1994·Cell·C A Janeway, K Bottomly
Oct 1, 1994·The Journal of Experimental Medicine·M J ShlomchikD Huszar
Jan 1, 1994·Annual Review of Immunology·M Z Radic, M Weigert
Apr 1, 1993·Immunology Today·M J Mamula, C A Janeway
Oct 1, 1993·International Immunology·M J ShlomchikM G Weigert
May 1, 1993·The Journal of Experimental Medicine·C MohanS K Datta
May 3, 1996·Cell·B L Kotzin
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·U MoensO P Rekvig
Mar 1, 1996·The Journal of Clinical Investigation·J E SalmonR P Kimberly
Jun 1, 1996·The Journal of Experimental Medicine·A KaliyaperumalS K Datta
Jun 1, 1996·Current Opinion in Immunology·A Lanzavecchia
Nov 1, 1996·Clinical Immunology and Immunopathology·L E DesJardinJ Schiffenbauer
Dec 1, 1996·Current Opinion in Immunology·T J Vyse, B L Kotzin
Jun 6, 1998·The Journal of Experimental Medicine·H KishimotoJ Sprent
Oct 31, 1998·Immunological Reviews·J A James, J B Harley
Oct 31, 1998·Immunological Reviews·J McCluskeyT P Gordon

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Citations

Aug 19, 2007·Immunologic Research·Seetha Monrad, Mariana J Kaplan
Feb 7, 2012·Archivum Immunologiae Et Therapiae Experimentalis·David Gómez-AlmaguerGuillermo J Ruiz-Arguelles
Jan 5, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Syamal K DattaLuting Xu
Jun 11, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alina SesarmanCassian Sitaru
Jun 2, 2006·Springer Seminars in Immunopathology·Mary K Crow
Apr 29, 2009·Zeitschrift für Rheumatologie·T AlexanderF Hiepe
Oct 22, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael Walsh, David Jayne
Dec 24, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stephen D Marks, Kjell Tullus
Aug 12, 2009·Modern Rheumatology·R John LooneyInaki Sanz
Oct 6, 2010·Journal of Clinical Immunology·Aharon KesselElias Toubi
Aug 9, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Likai YuXiaohua Hou
Sep 8, 2012·Current Allergy and Asthma Reports·Sheryl MascarenhasStacy P Ardoin
Sep 12, 2003·Current Rheumatology Reports·Jennifer AnolikR John Looney
Dec 21, 2011·Protein & Cell·Mayami Sengupta, Laurence Morel
Apr 1, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Stanford L Peng
Nov 5, 2002·Current Opinion in Immunology·Pamela S Ohashi, Anthony L DeFranco
Oct 11, 2003·Autoimmunity Reviews·Philippe KrebsBurkhard Ludewig
Jan 8, 2013·Cellular & Molecular Immunology·Min YangLiwei Lu
Mar 5, 2013·Cellular & Molecular Immunology·Vera Sau-Fong ChanChak-Sing Lau
Sep 25, 2008·Nature Clinical Practice. Neurology·Marinos C Dalakas
Feb 21, 2008·Nature Clinical Practice. Rheumatology·Nikolay P Nikolov, Steven Z Pavletic
Feb 17, 2006·Nature Immunology·Mark J MamulaGeorge C Tsokos
Nov 29, 2002·Nature Medicine·Gary M Kammer
Aug 7, 2009·Nature Reviews. Neurology·Barbara ThiloNicolas Lang
Oct 7, 2010·Nature Reviews. Rheumatology·Min Chen, Cees G M Kallenberg
May 12, 2010·Nature Reviews. Rheumatology·José C CrispínGeorge C Tsokos
Dec 5, 2002·Clinical and Experimental Dermatology·W Sterry, P Walden
Jun 18, 2004·The New England Journal of Medicine·George C Tsokos
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Rebecca A SweetMark J Shlomchik
Mar 19, 2003·The Journal of Experimental Medicine·Lynda BennettVirginia Pascual
Jul 21, 2004·The Journal of Experimental Medicine·Jonathan D HronStanford L Peng
Jul 20, 2005·The Journal of Experimental Medicine·Sean R ChristensenMark J Shlomchik
Nov 13, 2008·The Journal of Experimental Medicine·Vikas A GuptaArthur Weiss
Jul 14, 2010·The Journal of Experimental Medicine·Patrizia ScapiniClifford A Lowell
Aug 8, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Svjetlana LovricMarion Haubitz
Apr 23, 2003·Current Opinion in Rheumatology·Thomas Dörner, Gerd R Burmester
Sep 10, 2003·Current Opinion in Rheumatology·George C TsokosYuang-Taung Juang
Sep 10, 2003·Current Opinion in Rheumatology·Virginia PascualA Karolina Palucka
Oct 22, 2003·Current Opinion in Rheumatology·Michelle L Harris, Antony Rosen

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