From the bench to the bed: individualizing treatment in non-small-cell lung cancer.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Mariacarmela SantarpiaRafael Rosell

Abstract

At the time of diagnosis, half of lung cancer patients have advanced incurable disease. Different chemotherapy combinations--with or without targeted therapies--yield similar results in spite of the continuous efforts of clinicians. However, molecular biological studies have already shed a great deal of light on the existence of multiple genetic aberrations that can be useful for customizing treatment. mRNA transcripts involved in DNA repair pathways, such as ERCC1 and BRCA1, confer selective resistance to cisplatin or taxanes. Polymorphisms in DNA repair genes and methylation of checkpoint genes in circulating serum DNA could become important predictive markers of survival to certain cisplatin-based regimens. EGFR tyrosine kinase mutations are the crux of targeted therapies.

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Citations

Jun 6, 2007·Future Oncology·Rafael RosellLuis Paz-Ares
Aug 2, 2006·Clinical Lymphoma & Myeloma·Chris Schwab, Latha Shivakumar
Jun 6, 2006·IDrugs : the Investigational Drugs Journal·Yasuko Kondo, Seiji Kondo
Jun 27, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Martin Reck, Lucio Crinò
Aug 1, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A D Carvalho JúniorM C de Oliveira
Feb 4, 2009·Histopathology·William A H Wallace

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