From the hemangioblast to self-tolerance: a series of innovations gained from studies on the avian embryo

Mechanisms of Development
F Dieterlen-Lièvre, N Le Douarin

Abstract

During the last decades of the 20th century, studies on the vertebrate hematopoietic and immune systems have largely been performed, on mammalian models. The mouse has been the preferred material for several cogent reasons: (i) numerous well defined genetic strains are available; (ii) this species has been and still is instrumental in the study of gene activity through transgenesis; and (iii) in vitro culture techniques and in vivo assays for blood cells together with a wide array of antibodies and nucleic acid probes have been developed to investigate the cellular interactions occurring during hematopoiesis and immune reactivity. However, important and fundamental notions have emerged from using another higher vertebrate model, the avian embryo. The distinction among small lymphocytes of two populations, the T and B lymphocytes, endowed with different roles in adaptive immunity and dependant on different environments for their specification, has relied on experiments carried out in birds. The avian model has been critical for the analysis of the origin and traffic of hematopoietic precursor cells. It allowed the demonstration that both hematopoietic and angioblastic lineages arise from a common precursor, a cell whose existenc...Continue Reading

References

Jul 1, 1975·The Journal of Experimental Medicine·N M Le Douarin, F V Jotereau
Jan 1, 1977·Advances in Experimental Medicine and Biology·N M Le DouarinF Jotereau
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J SalaünA Coutinho
Jun 1, 1992·European Journal of Immunology·A BandeiraJ Salaün
Jan 1, 1989·International Immunology·M BeloN M Le Douarin
Apr 24, 1987·Cell·J W KapplerP Marrack
Aug 28, 1987·Science·H OhkiN M Le Douarin
Nov 1, 1986·Developmental Biology·F CormierF Dieterlen-Lièvre
Aug 1, 1971·The Australian Journal of Experimental Biology and Medical Science·D Metcalf
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B M PeaultN M Le Douarin
Jul 1, 1984·The American Journal of Anatomy·N M Le DouarinP D Oliver
Dec 1, 1984·The Journal of Experimental Medicine·F P GuillemotN M Le Douarin
Jan 1, 1980·Scandinavian Journal of Immunology·O LassilaF Dieterlen-Lièvre
Aug 1, 1980·European Journal of Immunology·F V JotereauN M Le Douarin
Nov 1, 1981·Developmental Biology·F Dieterlen-Lièvre, C Martin
Feb 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J WiltingB Christ
May 1, 1995·The Journal of Cell Biology·T Mustonen, K Alitalo
Feb 1, 1993·Anatomy and Embryology·L Pardanaud, F Dieterlen-Lièvre
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·A EichmannN M Le Douarin
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·A CaprioliF Dieterlen-Lièvre
Jan 5, 2000·The Journal of Clinical Investigation·S Rafii
Aug 6, 2000·Developmental Biology·T JaffredoF Dieterlen-Lièvre
Jan 11, 2002·Developmental Biology·A CaprioliT Jaffredo
Mar 9, 2002·Developmental Biology·Catherine Corbel, Josselyne Salaün
Jun 19, 1959·Science·J LEDERBERG

❮ Previous
Next ❯

Citations

Sep 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Joseph S Lipsick
Jul 3, 2008·Blood·Ricardo M B CostaEnrique Amaya
Feb 28, 2008·BMC Developmental Biology·Brendan A S McIntyreGuojun Sheng
Oct 29, 2008·Experimental Hematology·Tea Soon ParkBruno Péault
Feb 6, 2008·Comparative Immunology, Microbiology and Infectious Diseases·Jae Yong Han
Sep 24, 2005·Scandinavian Journal of Immunology·P SuonpääO Lassila
Jul 29, 2011·Annals of the New York Academy of Sciences·Gwonhwa Song, Jae Yong Han
Jan 9, 2013·Development, Growth & Differentiation·Yuki Sato
Apr 23, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jing-Wei Xiong
Jan 15, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Elaine F KungJeffrey S Schechner
Dec 3, 2008·Development, Growth & Differentiation·Yukiko Nakaya, Guojun Sheng
Dec 29, 2004·Developmental Cell·Claudio D Stern

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.