From where did the 2009 'swine-origin' influenza A virus (H1N1) emerge?

Virology Journal
Adrian J GibbsJean C Downie

Abstract

The swine-origin influenza A (H1N1) virus that appeared in 2009 and was first found in human beings in Mexico, is a reassortant with at least three parents. Six of the genes are closest in sequence to those of H1N2 'triple-reassortant' influenza viruses isolated from pigs in North America around 1999-2000. Its other two genes are from different Eurasian 'avian-like' viruses of pigs; the NA gene is closest to H1N1 viruses isolated in Europe in 1991-1993, and the MP gene is closest to H3N2 viruses isolated in Asia in 1999-2000. The sequences of these genes do not directly reveal the immediate source of the virus as the closest were from isolates collected more than a decade before the human pandemic started. The three parents of the virus may have been assembled in one place by natural means, such as by migrating birds, however the consistent link with pig viruses suggests that human activity was involved. We discuss a published suggestion that unsampled pig herds, the intercontinental live pig trade, together with porous quarantine barriers, generated the reassortant. We contrast that suggestion with the possibility that laboratory errors involving the sharing of virus isolates and cultured cells, or perhaps vaccine production, ...Continue Reading

References

Mar 1, 1992·Microbiological Reviews·R G WebsterY Kawaoka
Mar 1, 1997·The Journal of General Virology·I H BrownD J Alexander
Nov 11, 1999·Molecular Biology and Evolution·R M BushN J Cox
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·R M BushW M Fitch
May 30, 2002·Virus Research·Christopher W Olsen
Jul 29, 2006·Journal of Virology·Dmitriy ZamarinPeter Palese
Sep 1, 2006·Journal of Virology·Jürgen A RichtAdolfo García-Sastre
Nov 1, 2006·Emerging Infectious Diseases·Guang-Wu ChenShin-Ru Shih
Nov 17, 2007·Cell Host & Microbe·Gina M Conenello, Peter Palese
Jan 18, 2008·Journal of Clinical Microbiology·Hai YuGuang-Zhi Tong
Jul 8, 2008·Journal of Virological Methods·Mathieu FourmentMark J Gibbs
May 9, 2009·The New England Journal of Medicine·Fatimah S DawoodTimothy M Uyeki
May 9, 2009·The New England Journal of Medicine·Vivek ShindeLyn Finelli
May 13, 2009·Science·Christophe FraserUNKNOWN WHO Rapid Pandemic Assessment Collaboration
May 29, 2009·The New England Journal of Medicine·Vladimir TrifonovRaul Rabadan
Jun 2, 2009·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·A SolovyovR Rabadan
Jul 29, 2009·PloS One·Carl KingsfordSteven L Salzberg
Sep 9, 2009·Expert Review of Anti-infective Therapy·Scott E Hensley, Jonathan W Yewdell
Sep 22, 2009·Influenza and Other Respiratory Viruses·Christy Brockwell-StaatsRichard J Webby
Sep 24, 2009·Retrovirology·Alexander StangThomas Grunwald
Dec 22, 2009·Influenza and Other Respiratory Viruses·Irina KiselevaLarisa Rudenko
Feb 4, 2010·PLoS Currents·Alexander SolovyovRaul Rabadan
Jul 19, 2013·Journal of Virology·Ji-Young MinKanta Subbarao

❮ Previous
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Citations

Jun 5, 2013·Indian Journal of Virology : an Official Organ of Indian Virological Society·Madhu KhannaPrashant Kumar
Jul 2, 2010·Animal Health Research Reviews·Hadi M YassineYehia M Saif
Jun 24, 2010·Biosecurity and Bioterrorism : Biodefense Strategy, Practice, and Science·Arturo Casadevall, Michael J Imperiale
Feb 3, 2011·Molecular Biology and Evolution·Marc GottschlingIgnacio G Bravo
Mar 2, 2012·Journal of Virology·Lindomar PenaDaniel R Perez
Dec 16, 2010·Acta Veterinaria Scandinavica·István KissPer Wallgren
Feb 4, 2010·PLoS Currents·Alexander SolovyovRaul Rabadan
Oct 2, 2013·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·K HoschlerM Zambon
Mar 9, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mary C ChristmanGuoqing Lu
Nov 15, 2011·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Shahid H BokhariDaniel A Janies
Jun 20, 2012·Emerging Infectious Diseases·Huanliang YangHualan Chen
Aug 17, 2014·The Journal of General Virology·Alessio LorussoAmy L Vincent
Apr 2, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jonathan RunstadlerMandy Keogh
Jun 14, 2012·Critical Reviews in Microbiology·Dany Shoham
Feb 27, 2013·Acta Veterinaria Hungarica·Adám BálintAdám Dán
Jul 17, 2013·Journal of Virological Methods·Wiriya RutvisuttinuntStefan Fernandez
Aug 11, 2020·Médecine sciences : M/S·Erwan SallardÉtienne Decroly
Sep 24, 2020·Acta Cirúrgica Brasileira·Eiji Kobayashi
May 16, 2020·International Journal of Information Technology : an Official Journal of Bharati Vidyapeeth's Institute of Computer Applications and Management·Mohammad Yamin
Feb 10, 2021·Environmental Chemistry Letters·Erwan SallardJacques van Helden
Aug 11, 2021·Viruses·Yogesh B NarkhedeEva-Maria Strauch
Aug 10, 2021·Bulletin of the National Research Centre·Sankari MohanB Kishori

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Software Mentioned

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Basic Local Alignment Search Tool
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