Frondoside A induces AIF-associated caspase-independent apoptosis in Burkitt lymphoma cells

Leukemia & Lymphoma
Sergey A DyshlovoyGunhild von Amsberg

Abstract

For patients with refractory or relapsed Burkitt lymphoma (BL), no standard therapy is available for second-line treatment to date. Nonfunctional caspases-dependent apoptosis pathways, inactivating p53 mutations and pro-survival autophagy prevent activity of conventional chemotherapy. Thus, new drugs bypassing these mechanisms of resistance are required. Here, we investigated the efficacy of the marine natural compound frondoside A (FrA) in eight BL cell lines. FrA revealed cytotoxic effects in all cell lines tested including the multiresistant CA46 cells. Remarkably, FrA induced caspases- and p53-independent apoptosis, which was characterized by decreased expression of antiapoptotic survivin and Bcl-2, mitochondria targeting (release of cytochrome C, HtrA2/Omi and the apoptosis-inducing factor (AIF), and altered production of ROS) and translocation of AIF to the nuclei. In addition, signs of inhibition of pro-survival autophagy were observed. Thus, FrA is a promising candidate for the treatment of refractory or relapsed BL revealing resistances to standard therapies.

References

Aug 21, 1997·The New England Journal of Medicine·A IchikawaT Hotta
Jun 25, 1999·Cell Death and Differentiation·H K LorenzoG Kroemer
Dec 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hamdiye ErdalStig Linder
Feb 17, 2005·Nature Reviews. Molecular Cell Biology·Jerry E Chipuk, Douglas R Green
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Linda E BrökerGiuseppe Giaccone
Jul 15, 2005·Nature Medicine·Guido Kroemer, Seamus J Martin
Apr 8, 2006·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Qiang Yu
Jan 20, 2007·The Journal of Clinical Investigation·Ravi K AmaravadiCraig B Thompson
Nov 2, 2007·Nature Reviews. Cancer·Robin MathewEileen White
Sep 28, 2010·Antioxidants & Redox Signaling·Irina F Sevrioukova
Sep 1, 2011·Molecular Cancer Therapeutics·Zhineng J YangFrank A Sinicrope
Mar 14, 2012·Journal of Proteome Research·Sergey A DyshlovoyFriedemann Honecker
Feb 28, 2013·Journal of Hematology & Oncology·Xinyuan LiXiao-feng Yang
Mar 19, 2014·European Journal of Medicinal Chemistry·Dmitry N PelageevVictor Ph Anufriev
Nov 2, 2014·Blood·Dieter HoelzerUNKNOWN German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia
Mar 11, 2015·Marine Drugs·Dmitry L AmininVladimir I Kalinin
Nov 7, 2015·Marine Drugs·Sergey A Dyshlovoy, Friedemann Honecker
Dec 24, 2015·International Journal of Cancer. Journal International Du Cancer·Sergey A DyshlovoyGunhild von Amsberg

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Citations

Feb 22, 2018·Marine Drugs·Thomas E Adrian, Peter Collin
Feb 23, 2020·Marine Drugs·Emmanuel AmpofoMatthias W Laschke
Sep 25, 2020·Marine Drugs·Sergey A Dyshlovoy
Jan 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yue YangNing Li
Nov 10, 2021·Critical Reviews in Food Science and Nutrition·Yifan ZhouBaojun Xu

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