Frontal eye field signals that may trigger the brainstem saccade generator

Progress in Brain Research
Edward L KellerKyoung-Min Lee

Abstract

Saccades are rapid shifts of gaze that normally place the line of sight on a desired target with a single smooth movement. A number of disease states have been shown to result in saccadic movements that are fragmented, but still end near target position after a multi-step sequence of saccades. Among these disorders are Parkinson's disease and late-onset Tay-Sachs disease (LOTS). We have recently shown that normal human subjects and monkeys also make some two-step saccadic responses in cognitively difficult, choice response tasks. In monkeys we have been able to record neuronal responses as the animals performed a visually guided, choice saccade task. We compared the activity of neurons in the superior colliculus (SC) and the cortical frontal eye field (FEF) during the majority of trials that were accomplished with single-step saccades with those completed with two-step saccades. Several differences in discharge pattern aligned on the first saccade were uncovered. Neurons in the rostral and caudal SC were not modulated at the time of the first saccade, but a class of FEF neurons showed a burst of activity before the first saccade. If these neurons are among those known to project to the saccade generator in the brainstem, they c...Continue Reading

Citations

Jul 9, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Richard A ArmstrongNigel J Cairns
Mar 14, 2021·Journal of Computational Neuroscience·Jeffrey D Schall, Martin Paré

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