Frontal fibrosing alopecia: to treat or not to treat?

Journal of Cutaneous Medicine and Surgery
Eustathios RallisDimitrios Rigopoulos

Abstract

published studies have evaluated a variety of therapeutic agents in frontal fibrosing alopecia (FFA); however, data on whether fibrosis is already established when the patients initially present are scarce. to identify the prevalence of active disease in patients initially diagnosed with FFA and to evaluate the efficacy of therapeutic agents suggested in the medical literature. eighteen postmenopausal women with FFA presented at the outpatient clinic of our hospital from June 2003 to August 2007. Five patients who also presented with androgenetic alopecia were treated with finasteride 2.5 mg/d plus minoxidil 5% for 12 months. One patient with a rapidly regressing disease received systemic corticosteroids. The remaining 12 patients were divided into two groups: 6 patients received topical clobetasol 0.05% solution once daily for 6 months and the rest received no treatment. thirteen of 18 patients presented with stable disease. No significant improvement was observed in any of the patients. to date, there is no effective treatment proven with an appropriate level of evidence in the management of FFA. Exclusion criteria in future clinical studies should take into account patients presenting with stable disease. What needs to be es...Continue Reading

References

Jul 1, 1996·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·R FeldmannJ H Saurat
Jan 1, 1997·Journal of the American Academy of Dermatology·S KossardB Wilkinson
Jun 27, 1998·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·R M Trüeb, R Torricelli
Dec 5, 1998·The Australasian Journal of Dermatology·J R Sullivan, S Kossard
Mar 1, 2002·The Australasian Journal of Dermatology·Catherine F FaulknerStephen K Jones
Jul 23, 2002·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M StockmeierH Wolff
Jan 24, 2003·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M HeyerW Meigel
Feb 1, 2003·Clinical and Experimental Dermatology·E NazM Casado
Feb 1, 2003·Clinical and Experimental Dermatology·G DawnC S Munro
Jan 1, 2005·Journal of the American Academy of Dermatology·Antonella TostiCosimo Misciali
Mar 29, 2005·Journal of the American Academy of Dermatology·Paradi MirmiraniVera H Price
Apr 7, 2005·International Journal of Dermatology·Steven Kossard, Richard C Shiell
Jun 1, 2005·Annales de dermatologie et de vénéréologie·N JumezB Guillot
Nov 5, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·D Moreno-Ramírez, F Camacho Martínez
Nov 11, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Anke HerrmannJohannes Wohlrab
May 3, 2006·International Journal of Dermatology·Enrique PobletEnric Piqué
Oct 31, 2006·Annales de dermatologie et de vénéréologie·D DefoE Estève
Jul 31, 2007·Journal of the American Academy of Dermatology·Ossama AbbasSamer Ghosn
Aug 22, 2008·Dermatologic Therapy·Walter UngerCarlos Wesley
Aug 23, 2008·International Journal of Dermatology·Shigeki InuiSatoshi Itami
Sep 25, 2008·The British Journal of Dermatology·K T Tan, A G Messenger
May 6, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·A KatoulisN Stavrianeas

❮ Previous
Next ❯

Citations

Apr 8, 2014·Annales de dermatologie et de vénéréologie·C Jouanique, P Reygagne
Mar 28, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·E RáczH A M Neumann
Jan 24, 2014·BioMed Research International·Claudine Piérard-Franchimont, Gérald E Piérard
Jun 28, 2016·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·H AtarguineS Amal
Jan 25, 2017·Actas dermo-sifiliográficas·L Esteban-LucíaL Requena
Oct 24, 2017·Journal of Cutaneous Medicine and Surgery·Derek To, Jennifer Beecker
Jan 4, 2019·International Journal of Dermatology·Allison C HuNatasha A Mesinkovska
Dec 10, 2020·Clinical, Cosmetic and Investigational Dermatology·Reese Imhof, Stanislav N Tolkachjov
Jul 18, 2021·Clinics in Dermatology·Karolina L S KerkemeyerRodney D Sinclair

❮ Previous
Next ❯

Methods Mentioned

BETA
Biopsy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Academy of Dermatology
Sergio Vañó-GalvánF M Camacho
European Journal of Dermatology : EJD
Iolanda Conde FernandesSusana Machado
Journal of the American Academy of Dermatology
Alison MacDonaldSusan Holmes
© 2021 Meta ULC. All rights reserved