Frontal plane knee alignment is associated with a longitudinal reduction in patella cartilage volume in people with knee osteoarthritis

Osteoarthritis and Cartilage
A J TeichtahlF M Cicuttini

Abstract

Varus-valgus alignment of the knee is increasingly becoming recognised as an important biomechanical variable in patellofemoral osteoarthritis (OA). The aim of this study was to determine the cross-sectional and longitudinal relationships between frontal plane knee alignment and patella cartilage volume in people with knee OA. Ninety-nine adults with symptomatic knee OA were recruited using a combined strategy including referral from specialist centres, arthritis support groups and media advertising. Both baseline and follow-up X-rays and magnetic resonance imaging (MRI) were performed 2 years apart. Knee alignment and patella cartilage volume were determined from X-ray and MRI, respectively. Annual change in knee alignment was negatively associated with an annual change in the total patella cartilage volume before (P=0.002) and after (P=0.003) adjustment for potential confounders over an average of a 1.9-year period. For every 1 degrees change towards valgus direction, there was a 23.4-mm(3) [95% confidence interval (CI) 8.1 mm(3)-38.7 mm(3)] annual reduction in the total patella cartilage volume. This study is the first to clearly demonstrate and quantitate the annual reduction in patella cartilage volume that occurs as knee ...Continue Reading

References

Feb 1, 1996·Annals of the Rheumatic Diseases·F M CicuttiniT D Spector
Jul 18, 2000·Scandinavian Journal of Medicine & Science in Sports·J P ArokoskiH J Helminen
Aug 16, 2000·Arthritis and Rheumatism·S ElahiL Sharma
Sep 5, 2002·Arthritis and Rheumatism·Anita E WlukaFlavia M Cicuttini
Jul 13, 2004·Arthritis and Rheumatism·September CahueLeena Sharma

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Citations

Jun 8, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Per SwärdH Roos
Oct 10, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Angelique KoninckxEmmanuel Thienpont
Nov 3, 2011·Arthritis·Felix Eckstein, Wolfgang Wirth
Mar 16, 2012·Arthritis Research & Therapy·George PeatSara Muller
Feb 16, 2010·Maturitas·Andrew J TeichtahlFlavia M Cicuttini
Nov 26, 2009·Rheumatic Diseases Clinics of North America·Frank W RoemerAli Guermazi
Jul 28, 2009·Radiologic Clinics of North America·Felix EcksteinFrank W Roemer
Nov 15, 2014·Medicine and Science in Sports and Exercise·Michelle HallKim L Bennell
Mar 15, 2011·Osteoarthritis and Cartilage·D J HunterE Losina
Apr 9, 2017·Annals of the Rheumatic Diseases·Garifallia SakellariouAnnamaria Iagnocco
Jun 7, 2019·Journal of Pediatric Orthopedics·Philip K McClure, John E Herzenberg
Aug 24, 2021·Applied Bionics and Biomechanics·Elizabeth WhissellZhen Wei

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