Frontal-striatal connectivity and positive symptoms of schizophrenia: implications for the mechanistic basis of prefrontal rTMS.

European Archives of Psychiatry and Clinical Neuroscience
Roberto LimongiLENA PALANIYAPPAN

Abstract

Repetitive transcranial magnetic stimulation (rTMS), when applied to left dorsolateral prefrontal cortex (LDLPFC), reduces negative symptoms of schizophrenia, but has no effect on positive symptoms. In a small number of cases, it appears to worsen the severity of positive symptoms. It has been hypothesized that high-frequency rTMS of the LDLPFC might increase the dopaminergic neurotransmission by driving the activity of the left striatum in the basal ganglia (LSTR)-increasing striatal dopaminergic activity. This hypothesis relies on the assumption that either the frontal-striatal connection or the intrinsic frontal and/or striatal connections covary with the severity of positive symptoms. The current work aimed to evaluate this assumption by studying the association between positive and negative symptoms severity and the effective connectivity within the frontal and striatal network using dynamic causal modeling of resting state fMRI in a sample of 19 first episode psychosis subjects. We found that the total score of positive symptoms of schizophrenia is strongly associated with the frontostriatal circuitry. Stronger intrinsic inhibitory tone of LDLPFC and LSTR, as well as decreased bidirectional excitatory influence between th...Continue Reading

References

Aug 1, 1982·Archives of General Psychiatry·J F LeckmanM M Weissman
Dec 1, 1995·Archives of General Psychiatry·J W Olney, N B Farber
Jan 1, 1996·Harvard Review of Psychiatry·J T Coyle
Dec 1, 1999·Biological Psychiatry·A CarlssonM L Carlsson
Sep 2, 2003·NeuroImage·K J FristonW Penny
Dec 20, 2003·Annals of the New York Academy of Sciences·Marc LaruelleAnissa Abi-Dargham
Mar 3, 2005·The American Journal of Psychiatry·Nancy C AndreasenDaniel R Weinberger
Oct 16, 2007·NeuroImage·A C MarreirosK J Friston
Mar 25, 2009·NeuroImage·Klaas Enno StephanKarl J Friston
Mar 28, 2009·Schizophrenia Bulletin·Oliver D Howes, Shitij Kapur
Nov 29, 2012·Frontiers in Pharmacology·Thomas L SchwartzStephen M Stahl
Apr 2, 2013·Frontiers in Cellular Neuroscience·Melissa A Snyder, Wen-Jun Gao
Feb 22, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Juanjuan RenPaolo Maria Rossini
Dec 3, 2014·NeuroImage·Adeel RaziKarl J Friston
May 11, 2015·Schizophrenia Research·Tyler S KasterZafiris J Daskalakis
Jul 3, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tobias GleichJürgen Gallinat
Sep 9, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas P WhiteSukhwinder S Shergill
Nov 17, 2015·NeuroImage·Karl J FristonPeter Zeidman
Dec 8, 2015·Frontiers in Systems Neuroscience·Karl FristonVladimir Litvak
Feb 22, 2017·NeuroImage·K J FristonPeter Zeidman
Feb 8, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·Nigel I KennedySophia Frangou
Apr 14, 2019·Schizophrenia Research·Melissa A Snyder, Wen-Jun Gao
Aug 15, 2019·Current Psychiatry Reports·Urvakhsh Meherwan MehtaJagadisha Thirthalli
Aug 16, 2019·Neuropsychiatric Disease and Treatment·Clément NathouSonia Dollfus
Feb 23, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Elias WagnerAlkomiet Hasan

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