Frontal versus transcorneal stimulation to induce maximal electroshock seizures or kindling in mice and rats

Epilepsy Research
P WlaźW Löscher

Abstract

Frontal stimulation, i.e. electrical stimulation where electrodes are pressed on the skin of the intact frontal skull of mice or rats, may represent a more humane alternative to the widely used transcorneal stimulation to induce electroshock seizures. The aim of this work was to directly compare transcorneal and frontal stimulation in eliciting maximal electroshock-induced seizures (MES) in mice and the anticonvulsant effect of carbamazepine (CBZ) and phenytoin (PHT) on thus produced seizures. In addition, we stimulated mice and rats repeatedly via transcorneal and frontal electrodes to see whether kindling is produced by this procedure. Two electroshock tests were used in mice, i.e. maximal electroshock seizure threshold (MEST) test and MES generated by supramaximal stimulation (50 mA). Frontal stimulation resulted in lower convulsive threshold than in the case of corneal stimulation. Both CBZ and PHT produced dose-dependent increases in seizure threshold for both sites of stimulation, i.e. transcorneal and frontal. As regards type of electrodes, higher doses of PHT were required to increase seizure threshold in the case of frontal than transcorneal stimulation. Supramaximal stimulation (50 mA) yielded comparable ED50 values r...Continue Reading

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine

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Citations

Aug 31, 2007·Journal of Neural Transmission·D NieoczymP Wlaź
Aug 24, 2007·Experimental Neurology·Ina GrötickeWolfgang Löscher
Nov 10, 2007·Journal of Veterinary Pharmacology and Therapeutics·P R TerritoH E Shannon
Feb 26, 2015·Pharmacological Reports : PR·Piotr WlaźChris Rundfeldt
Jun 21, 2001·Genomics·W N FrankelH S White
Sep 24, 2004·Neuroscience Letters·Lucas Henrique Maia MagalhãesMárcio Flávio Dutra Moraes
Jun 1, 2009·Current Protocols in Pharmacology·William J Giardina, Maciej Gasior

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