Frontiers in hormone therapy for male infertility

Translational Andrology and Urology
Iyad KhourdajiRyan P Smith

Abstract

For a significant number of couples worldwide, infertility is a harsh reality. As specialists in male infertility, much of our armamentarium lacks definitive, evidence-based therapies. For years, we have relied on manipulation of the male hormonal axis to treat those men who help carry the burden of infertility in their partnerships. Indeed, male factor infertility is the sole component of infertility in at least 20% of couples. Further compounding this dilemma is that 25% to 50% of males with infertility have no identifiable etiology and thus present a true management conundrum. This manuscript is an attempt to clarify what therapies exist for the treatment of male factor infertility. We have reviewed the relevant infertility literature honing, our focus on hormonal anomalies and their subsequent impact on fertility. Many of the therapies discussed have been utilized in practice for generations. Thus, this article attempts to provide the evidence-based literature to support the continued use of the current treatment paradigm. Furthermore, we recognize that any review beckons a discussion of what challenges and therapies await on the horizon. For instance, there has been significant interest in restoring spermatogenesis after t...Continue Reading

Citations

Nov 7, 2019·Andrology·UNKNOWN Cairo Consensus Workshop Group
Nov 30, 2019·Reproductive Biology and Endocrinology : RB&E·Pan GeDang-Xia Zhou
Jan 1, 2020·Basic and Clinical Andrology·Aimé Césaire Momo TetsatsiPierre Watcho
Nov 25, 2020·Annual Review of Genetics·Nahid Punjani, Dolores J Lamb
Apr 20, 2021·Food Science and Biotechnology·Kyeong Soo LeeYoung Geol Yoon
Apr 29, 2021·International Journal of Stem Cells·Lei WangZhaojin Du

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BETA
biopsy
contraception
gastric bypass

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