Frontiers in non-union research

EFORT Open Reviews
Enrique Gómez-BarrenaPhilippe Rosset

Abstract

Multifactorial aetiology defines non-unions, with a biological and a mechanical distortion of the timeline of bone healing.Research on new advances to increase osteogenesis and promote non-union healing is strongly directed towards new forms of cell products.Basic science and research on non-union treatments is needed to compile preclinical data on new treatments.Bone marrow concentration and expanded mesenchymal stromal cells still require extensive clinical research to confirm efficacy in non-union treatment.Solid preclinical studies, precise cell product definition and preparation, and appropriate ethical and regulatory approvals are needed to assess new advanced therapy medicinal products. Cite this article: EFORT Open Rev 2020;5:574-583. DOI: 10.1302/2058-5241.5.190062.

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Methods Mentioned

BETA
bone marrow centrifugation

Clinical Trials Mentioned

NCT00424567
NCT00916981
NCT01206179
NCT01429012
NCT01435434
NCT01813188
NCT01756326
NCT01788059
NCT01842477
NCT02020590

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