Frontline Science: Mast cells regulate neutrophil homeostasis by influencing macrophage clearance activity

Journal of Leukocyte Biology
Elena JachettiBarbara Frossi

Abstract

The receptor tyrosine kinase cKit and its ligand stem cell factor are essential for mast cells (MC) development and survival. Strains with mutations affecting the Kit gene display a profound MC deficiency in all tissues and have been extensively used to investigate the role of MC in both physiologic and pathologic conditions. However, these mice present a variety of abnormalities in other immune cell populations that can affect the interpretation of MC-related responses. C57BL/6 KitW-sh are characterized by an aberrant extramedullary myelopoiesis and systemic neutrophilia. MC deficiency in KitW-sh mice can be selectively repaired by engraftment with in vitro-differentiated MC to validate MC-specific functions. Nevertheless, the impact of MC reconstitution on other immune populations has never been evaluated in detail. Here, we specifically investigated the neutrophil compartment in primary and secondary lymphoid organs of C57BL/6 KitW-sh mice before and after MC reconstitution. We found that, albeit not apparently affecting neutrophils phenotype or maturation, MC reconstitution of KitW-sh mice restored the number of neutrophils at a level similar to that of wild-type C57BL/6 mice. In vitro and ex vivo experiments indicated that...Continue Reading

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Citations

Feb 23, 2019·Journal of Leukocyte Biology·Mihaela Gadjeva
May 13, 2020·Neural Regeneration Research·Karen Henriette PinkeAlexandrina Sartori
Feb 13, 2020·Frontiers in Medicine·Lian WangXian Jiang
Mar 2, 2021·Frontiers in Immunology·Lisa KornstädtKlaus Scholich

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