Frontline Science: Rapid adipose tissue expansion triggers unique proliferation and lipid accumulation profiles in adipose tissue macrophages

Journal of Leukocyte Biology
Lindsey A MuirCarey N Lumeng

Abstract

Obesity-related changes in adipose tissue leukocytes, in particular adipose tissue macrophages (ATMs) and dendritic cells (ATDCs), are implicated in metabolic inflammation, insulin resistance, and altered regulation of adipocyte function. We evaluated stromal cell and white adipose tissue (WAT) expansion dynamics with high fat diet (HFD) feeding for 3-56 days, quantifying ATMs, ATDCs, endothelial cells (ECs), and preadipocytes (PAs) in visceral epididymal WAT and subcutaneous inguinal WAT. To better understand mechanisms of the early response to obesity, we evaluated ATM proliferation and lipid accumulation. ATMs, ATDCs, and ECs increased with rapid WAT expansion, with ATMs derived primarily from a CCR2-independent resident population. WAT expansion stimulated proliferation in resident ATMs and ECs, but not CD11c+ ATMs or ATDCs. ATM proliferation was unperturbed in Csf2- and Rag1-deficient mice with WAT expansion. Additionally, ATM apoptosis decreased with WAT expansion, and proliferation and apoptosis reverted to baseline with weight loss. Adipocytes reached maximal hypertrophy at 28 days of HFD, coinciding with a plateau in resident ATM accumulation and the appearance of lipid-laden CD11c+ ATMs in visceral epididymal WAT. ATM...Continue Reading

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Citations

Mar 14, 2018·Journal of Leukocyte Biology·Susan K Fried
Jun 13, 2018·Journal of Lipid Research·W Reid Bolus, Alyssa H Hasty
Feb 14, 2020·International Journal of Food Sciences and Nutrition·Talitha Silva MeneguelliJosefina Bressan
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Nov 2, 2018·International Journal of Molecular Sciences·Abdelnaby KhalyfaDavid Gozal
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Aug 28, 2021·International Journal of Molecular Sciences·Shindy Soedono, Kae Won Cho
Sep 3, 2021·Mechanisms of Ageing and Development·Mita VargheseKanakadurga Singer

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