Fronto-insula network activity explains emotional dysfunctions in juvenile myoclonic epilepsy: combined evidence from pupillometry and fMRI

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Frieder Michel PaulusSusanne Knake

Abstract

Emotional instability, difficulties in social adjustment, and disinhibited behavior are the most common symptoms of the psychiatric comorbidities in juvenile myoclonic epilepsy (JME). This psychopathology has been associated with dysfunctions of mesial-frontal brain circuits. The present work is a first direct test of this link and adapted a paradigm for probing frontal circuits during empathy for pain. Neural and psychophysiological parameters of pain empathy were assessed by combining functional magnetic resonance imaging (fMRI) with simultaneous pupillometry in 15 JME patients and 15 matched healthy controls. In JME patients, we observed reduced neural activation of the anterior cingulate cortex (ACC), the anterior insula (AI), and the ventrolateral prefrontal cortex (VLPFC). This modulation was paralleled by reduced pupil dilation during empathy for pain in patients. At the same time, pupil dilation was positively related to neural activity of the ACC, AI, and VLPFC. In JME patients, the ACC additionally showed reduced functional connectivity with the primary and secondary somatosensory cortex, areas fundamentally implicated in processing the somatic cause of another's pain. Our results provide first evidence that alteratio...Continue Reading

References

Jun 1, 1984·The American Journal of Psychiatry·G J Taylor
May 1, 1995·Comprehensive Psychiatry·B J CoxD Bourdeau
Aug 28, 2001·Journal of the American Medical Informatics Association : JAMIA·D C Van EssenC H Anderson
May 8, 2002·Nature Reviews. Neuroscience·Matthew BrettAdrian M Owen
Aug 28, 2003·Journal of Child Neurology·Krishna B DasJ Helen Cross
Mar 9, 2004·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Stuart R SteinhauerMisha Pless
Jul 6, 2005·NeuroImage·Hugo D CritchleyRaymond J Dolan
May 17, 2006·NeuroImage·Luiz Eduardo BettingFernando Cendes
Nov 30, 2006·Human Brain Mapping·Falk EippertSilke Anders
Mar 9, 2007·Trends in Cognitive Sciences·Christian Keysers, Valeria Gazzola
May 19, 2007·Epilepsia·Philippe GélissePierre Gentin
Feb 20, 2008·Psychophysiology·Margaret M BradleyPeter J Lang
Jul 18, 2008·Social Neuroscience·Giorgia SilaniUta Frith
Dec 20, 2008·Nature Reviews. Neuroscience·A D Bud Craig
May 2, 2009·Science·Christine EsslingerAndreas Meyer-Lindenberg
May 16, 2009·Science·Dean MobbsTim Dalgleish
Apr 8, 2010·Brain : a Journal of Neurology·Geoffrey BirdTania Singer
Dec 3, 2010·NeuroImage·Carrie L MastenNaomi I Eisenberger
Jan 6, 2011·Neurology·J O'MuircheartaighM P Richardson
May 3, 2011·PloS One·Sören KrachFrieder Michel Paulus
Oct 14, 2011·Frontiers in Neuroscience·Kerstin PreuschoffWolfgang Einhäuser
Nov 2, 2011·Human Brain Mapping·Frieder M PaulusAndreas Jansen
Feb 10, 2012·Developmental Cognitive Neuroscience·Carrie L MastenMirella Dapretto
Dec 20, 2012·Brain : a Journal of Neurology·Jonathan O'MuircheartaighMark P Richardson
Mar 21, 2013·Epilepsy & Behavior : E&B·Gerardo Maria de Araujo FilhoAndrea Parolin Jackowski

❮ Previous
Next ❯

Citations

Jun 21, 2015·NeuroImage·L Müller-PinzlerS Krach
May 16, 2017·Human Brain Mapping·Davide LaneriLaura Müller-Pinzler
Nov 29, 2017·Brain Structure & Function·Michał KunieckiJoanna Pilarczyk
Oct 1, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Valentina GaribottoFabienne Picard
Oct 18, 2020·Seizure : the Journal of the British Epilepsy Association·André Peres GamaLaura Maria Guilhoto
Nov 18, 2021·Brain Imaging and Behavior·Hossein Sanjari MoghaddamAbbas Tafakhori

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Brain Imaging of Neural Circuits

Neural circuits are groups of interconnected neurons which carry out specific functions when activated. Imaging these neural circuits allows researches to further elucidate their mechanisms and functions. Follow this feed to stay up to date on brain imaging of neural circuits.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Brain Circuits in Emotional Learning

The neuronal circuits within the cortico-limbic brain regions form networks that mediate emotional behavior. Areas specific to emotional learning include the basal amygdala and sublenticular extended amygdala region along with a supplemental motor area. Discover the latest research on brain circuits in emotional learning here.

Brain Imaging of Neural Circuits (MDS)

Neural circuits are groups of interconnected neurons which carry out specific functions when activated. Imaging these neural circuits allows researches to further elucidate their mechanisms and functions. Follow this feed to stay up to date on brain imaging of neural circuits.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.