Fronto-Insular Connectivity during Pain Distraction Is Impaired in Patients with Somatoform Pain

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Anne StankewitzThomas R Tölle

Abstract

Somatoform pain disorder is characterized by chronic pain and various psychological symptoms including increased attention to mental and physical processes. Given that the medial prefrontal cortex (mPFC) of the default mode network (DMN) and the anterior insula of the salience network are critically involved in intrinsic and attentional processes, we investigated the involvement of these networks during the distraction from physical pain in somatoform pain patients. During painful and nonpainful heat stimulation, attentional distraction from physical processes was modulated with a Stroop task. Thirteen patients were investigated with functional magnetic resonance imaging (fMRI) and compared to 13 controls. Main outcomes were spatial maps of coherent fMRI activity based on independent component analysis and functional connectivity (FC) resulting from psychophysiological interaction analysis. Behavioral pain intensity ratings were reduced during the distraction task in both groups. At brain level, we found deviant network activities in the DMN (particularly in the mPFC) and in the salience network (bilaterally in the anterior insula) in patients. During pain stimulation, Stroop-induced distraction decreased the FC between the mPF...Continue Reading

References

Apr 1, 1990·Journal of Personality and Social Psychology·D P Devine, N P Spanos
Nov 1, 1995·Neural Computation·A J Bell, T J Sejnowski
Nov 5, 1997·NeuroImage·K J FristonR J Dolan
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·D A GusnardM E Raichle
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Aug 2, 2005·Trends in Cognitive Sciences·Anthony D WagnerRandy L Buckner
Oct 29, 2005·The Journal of Comparative Neurology·Hugo D Critchley
Dec 6, 2005·European Archives of Psychiatry and Clinical Neuroscience·Christine FröhlichHans-Ulrich Wittchen
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Mar 21, 2007·Lancet·Peter HenningsenWolfgang Herzog
May 8, 2007·Pain·David A Seminowicz, Karen D Davis
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·D MantiniM Corbetta
Aug 7, 2007·Neuron·Irene Tracey, Patrick W Mantyh
Dec 8, 2007·Cerebral Cortex·J S DamoiseauxS A R B Rombouts
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marwan N BalikiDante R Chialvo
Mar 12, 2008·Current Opinion in Psychiatry·Winfried RiefPaul Nilges
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Dec 20, 2008·Nature Reviews. Neuroscience·A D Bud Craig
Feb 21, 2009·PloS One·Franco CaudaSergio Canavero
Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sanna MalinenRiitta Hari
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Nov 15, 2011·The British Journal of Psychiatry : the Journal of Mental Science·H SattelP Henningsen
Feb 2, 2012·Arthritis and Rheumatism·Vitaly NapadowRichard E Harris
Feb 20, 2013·Frontiers in Human Neuroscience·Gennady G Knyazev
May 31, 2013·Nature Reviews. Neuroscience·M Catherine BushnellLucie A Low
Sep 12, 2013·Pain·Luis Garcia-Larrea, Roland Peyron
Mar 14, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron KucyiKaren D Davis
May 13, 2014·The Journal of Pain : Official Journal of the American Pain Society·Eric IchescoRichard E Harris
Jun 4, 2014·Cyberpsychology, Behavior and Social Networking·Desirée Loreto-QuijadaLiudmila Liutsko
Mar 13, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christian SprengerChristian Büchel
Dec 25, 2015·Lancet Neurology·Troels S Jensen, Nanna B Finnerup
May 18, 2016·Brain : a Journal of Neurology·Etienne Vachon-PresseauA Vania Apkarian
Nov 22, 2017·NeuroImage. Clinical·Z AlshelhL A Henderson

❮ Previous
Next ❯

Citations

Nov 14, 2019·European Archives of Psychiatry and Clinical Neuroscience·Qi HuangFengchun Hua
Oct 4, 2019·Pain Reports·Elizabeth A NeckaLauren Y Atlas
May 20, 2019·Pain Practice : the Official Journal of World Institute of Pain·Claudio Bascour-SandovalGermán Gálvez-García

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.