Fronto-temporal alterations within the first 200 ms during an attentional task distinguish major depression, non-clinical participants with depressed mood and healthy controls: a potential biomarker?

Human Brain Mapping
Andrew H KempLeanne M Williams

Abstract

Attentional impairment in depression is a cardinal feature of depression and has been proposed as a candidate endophenotype for major depressive disorder. Event-related potentials (ERPs) elicited by oddball signal detection tasks provide objective markers of selective stimulus processing, and are pertinent endophenotypic markers for depression. While previous studies have sought to determine objective markers for attentional impairment in depression, evidence is inconsistent and may involve heterogeneity in relatively small samples. Here, we brought together oddball ERP recording with source localization of neural correlates of selective attention in outpatients with major depressive disorder (MDD; n = 78) and participants with depressed mood (PDM; n = 127) relative to healthy controls (CTL; n = 116). The key finding was a dimensional exaggeration of the P200 (140-270 ms) to both target (signal) and non-target (noise) stimuli, most pronounced in MDD, followed by PDM, relative to CTL. This exaggeration was coupled with slower and more variable response times, suggesting that neural systems are attempting to compensate for a difficulty in discriminating signal from noise. P200 alterations were localised to limbic (hippocampal), t...Continue Reading

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Citations

Oct 3, 2009·Psychological Medicine·D P GoldbergM J Hobbs
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mayuresh S KorgaonkarLeanne M Williams
Jan 22, 2013·Psychiatry and Clinical Neurosciences·Tsu-Wang ShenShao-Tsu Chen
Jan 29, 2013·Neuropsychiatric Disease and Treatment·Anusha BaskaranRoger S McIntyre
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Aug 19, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Rik van DinterenLeanne M Williams
Sep 11, 2009·Journal of Affective Disorders·Andrew H KempLeanne M Williams
Jun 25, 2016·Journal of Psycholinguistic Research·Marlena Bartczak, Barbara Bokus
Apr 18, 2012·The Australian and New Zealand Journal of Psychiatry·Candice R QuinnAndrew H Kemp
Sep 16, 2017·Journal of Clinical and Experimental Neuropsychology·Jaroslav Slobodskoy-Plusnin
Nov 9, 2019·Translational Psychiatry·Arielle S KellerLeanne M Williams
Jun 25, 2020·Clinical EEG and Neuroscience·Paniz TavakoliKenneth Campbell
Jan 15, 2019·Nordic Journal of Psychiatry·Lina ZhouHanping Bai
Dec 3, 2014·Journal of Affective Disorders·E GreimelG Schulte-Körne

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