Frontolimbic functioning during threat-related attention: Relations to early behavioral inhibition and anxiety in children

Biological Psychology
Xiaoxue FuKoraly E Pérez-Edgar

Abstract

Children with behavioral inhibition (BI), a temperament characterized by biologically-based hyper-vigilance to novelty, display threat-related attention biases (AB) that shape developmental trajectories of risk for anxiety. Here we explore the relations between BI, neural function, and anxiety. Fifty-six 9-12-year-olds (23 behaviorally inhibited) performed the dot-probe task while undergoing fMRI. AB scores were not associated with BI group or parent-rated anxiety symptoms. Trials requiring attention orienting away from threat engaged an executive and threat-attention network (dlPFC, vlPFC, mPFC, and amygdala). Within that network, behaviorally inhibited children showed greater activation in the right dlPFC. Heightened dlPFC activation related to increased anxiety, and BI levels accounted for the direct relation between dlPFC activation and anxiety. Behaviorally inhibited children may engage the executive attention system during threat-related processing as a compensatory mechanism. We provide preliminary evidence that the link between PFC functioning and anxiety might be attributed to early-emerging temperamental vulnerabilities present before the emergence of clinical anxiety.

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Citations

Apr 12, 2016·Developmental Cognitive Neuroscience·Nhi ThaiKoraly E Pérez-Edgar
Aug 28, 2016·Journal of the American Academy of Child and Adolescent Psychiatry·Jacqueline Alexandra ClaussJennifer Urbano Blackford
Sep 9, 2016·Developmental Cognitive Neuroscience·Santiago MoralesKoraly E Pérez-Edgar
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Oct 25, 2020·Developmental Science·Abigail Thompson, Nikolaus Steinbeis
Apr 24, 2021·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Robert D TorrenceJoshua M Carlson
Jun 3, 2021·International Journal of Environmental Research and Public Health·Francesca AgostiniErica Neri
Jun 1, 2021·Child and Adolescent Psychiatric Clinics of North America·Ellen Leibenluft, Katharina Kircanski
Aug 18, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Margaux M KenwoodHelen Barbas

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