Frontoparietal activation during delayed visuospatial recall in patients with epilepsy due to hippocampal sclerosis

Epilepsy & Behavior : E&B
Bernt A EngelsenKenneth Hugdahl

Abstract

We hypothesized that brain activation during encoding and retrieval of visual material differed between epilepsy patients with hippocampal sclerosis (HS) and healthy controls. Eleven patients with epilepsy and HS and nine age- and education-matched control subjects were tested during functional MRI recording. A three-block design for visuospatial memory encoding and retrieval and an interference interval longer than 1 minute without memory tasks were used. All subjects revealed parietal, occipital, and prefrontal activation patterns during encoding. Interference revealed parietal more than occipital activation, whereas retrieval revealed asymmetrical frontal and parietal activation. Patients demonstrated a relative increase in occipitoparietal versus frontal cortical activation as compared with controls. Memory performance did not differ between patients and controls. The increased activation in occipitoparietal versus frontal areas in the patients suggests cortical reorganization of visuospatial recognition memory in epilepsy patients with HS. The study is limited by other factors that may contribute to the results, for example, antiepileptic drugs, effects of greater cognitive effort allocated in patients than controls, and p...Continue Reading

References

Sep 30, 1977·Annals of the New York Academy of Sciences·T Rasmussen, B Milner
Aug 1, 1988·Journal of Clinical and Experimental Neuropsychology·B P HermannE T Richey
Dec 1, 1980·Epilepsia·A M Dam
Dec 1, 1994·Annals of Neurology·T R HenryP H Crandall
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·E TulvingS Houle
Apr 1, 1996·Journal of Clinical and Experimental Neuropsychology·M D HornerR A Bakay
Dec 1, 1995·Journal of Clinical and Experimental Neuropsychology·B Hermann, M Seidenberg
Jan 1, 1997·Annals of Neurology·W Van PaesschenJ S Duncan
Sep 1, 1995·NeuroImage·P C FletcherR J Dolan
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·L G UngerleiderJ V Haxby
Jul 2, 1998·Brain : a Journal of Neurology·M M Mesulam
Aug 15, 1998·Journal of Neurophysiology·M ColomboC G Gross
Jan 9, 1999·Hippocampus·M B Moser, E I Moser
Mar 11, 1999·Annals of Neurology·C J PlonerC Pierrot-Deseilligny
Jun 17, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·H Jokeit, A Ebner
Apr 19, 2000·Journal of Cognitive Neuroscience·R Cabeza, L Nyberg
May 12, 2000·NeuroImage·E K Miller
Mar 17, 2001·Nature Reviews. Neuroscience·H Eichenbaum
Mar 23, 2001·Current Opinion in Neurology·C Helmstaedter, M Kurthen
May 4, 2001·Brain : a Journal of Neurology·P C Fletcher, R N Henson
Aug 15, 2001·Scandinavian Journal of Psychology·L Nyberg
Sep 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·N BurgessJ O'Keefe
Sep 26, 2001·Brain : a Journal of Neurology·S A BungeJ D Gabrieli
Nov 28, 2001·Neurology·H JokeitF G Woermann
Dec 18, 2001·Neurocase·H J SpiersN Burgess
Jul 12, 2002·Annals of Neurology·Charles Pierrot-DeseillignyChristoph J Ploner
Aug 16, 2002·Epilepsia·Alexandra J GolbyJohn D E Gabrieli
May 10, 2003·Epilepsy & Behavior : E&B·Melanie B. Shulman
Jun 14, 2003·Trends in Cognitive Sciences·Reza HabibEndel Tulving
Aug 2, 2003·Nature Reviews. Neuroscience·Jon S Simons, Hugo J Spiers
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER
Apr 15, 2004·Current Opinion in Neurobiology·Marlene BehrmannSarah Shomstein
May 10, 2005·Epilepsy & Behavior : E&B·Rachel E Goldmann, Alexandra J Golby
Jan 1, 1997·Journal of Cognitive Neuroscience·R Cabeza, L Nyberg

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Citations

Jun 4, 2011·Epilepsia·Marielle C G VlooswijkWalter H Backes
Mar 15, 2008·Clinical Neurology and Neurosurgery·Marielle C G VlooswijkAlbert P Aldenkamp

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