Frontoparietal Cortical Thinning in Respiratory-Type Panic Disorder: A Preliminary Report

Psychiatry Investigation
Ho-Kyoung YoonByung-Joo Ham

Abstract

Many evidences raise the possibility that the panic disorder (PD) patients with respiratory subtype (RS) may have characteristic structural abnormalities. We aimed to explore the structural differences between PD patients with and without the respiratory symptoms. Patients with PD were recruited from the Department of Psychiatry at Korea University Anam Hospital. Respiratory subtype (RS) was diagnosed when at least 4 out of 5 of the following respiratory symptoms were present during the panic attack: fear of dying, chest pain/discomfort, shortness of breath, paresthesias, and a choking sensation. We acquired high-resolution MRI scans and used FreeSurfer to obtain a measure of cortical thickness for each patient. Cluster based analysis revealed significantly decreased cortical thickness in the left hemisphere in the caudal-middle-frontal, superior frontal, and posterior parietal areas in the RS group. No significant difference was observed in any of the limbic areas. Respiratory symptoms of panic disorder were associated with a reduction in cortical thickness in the left frontal and parietal areas. This finding leads to the assumption that the frontoparietal network is the crucial component in a larger cortical network underlyin...Continue Reading

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Citations

Sep 5, 2018·Psychiatry Investigation·Chien-Han Lai
Feb 20, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Renata T OkuroAntonio E Nardi
Jun 7, 2021·Neuroscience and Biobehavioral Reviews·Anne Margarette S MaalloScott A Holmes

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Software Mentioned

SPSS
FreeSurfer

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