Aug 8, 2014

Frontoparietal representations of task context support the flexible control of goal-directed cognition

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Michael L WaskomAnthony D Wagner

Abstract

Cognitive control allows stimulus-response processing to be aligned with internal goals and is thus central to intelligent, purposeful behavior. Control is thought to depend in part on the active representation of task information in prefrontal cortex (PFC), which provides a source of contextual bias on perception, decision making, and action. In the present study, we investigated the organization, influences, and consequences of context representation as human subjects performed a cued sorting task that required them to flexibly judge the relationship between pairs of multivalent stimuli. Using a connectivity-based parcellation of PFC and multivariate decoding analyses, we determined that context is specifically and transiently represented in a region spanning the inferior frontal sulcus during context-dependent decision making. We also found strong evidence that decision context is represented within the intraparietal sulcus, an area previously shown to be functionally networked with the inferior frontal sulcus at rest and during task performance. Rule-guided allocation of attention to different stimulus dimensions produced discriminable patterns of activation in visual cortex, providing a signature of top-down bias over perc...Continue Reading

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Mentioned in this Paper

Structure of Intraparietal Sulcus
Dioxygen
Inferior Frontal Sulcus (Human Only)
Prefrontal Cortex
Cues
Reaction Time
Visual Perception
Optical Image Reconstruction
Objective (Goal)
Sorting - Cell Movement

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