Frontotemporal Dementia and Psychiatric Illness: Emerging Clinical and Biological Links in Gene Carriers

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Nikolas R BlockHoward J Rosen

Abstract

To describe psychiatric presentations in individuals with genetic mutations causing frontotemporal dementia (FTD). Case descriptions from five carriers of FTD-related gene mutations with symptoms associated with non-neurodegenerative psychiatric disease. A comprehensive research program investigating genetic and non-genetic FTD at the University of California, San Francisco Memory and Aging Center. Three proband and two non-proband gene carriers. Medical history and neurological examination, neuropsychological testing, magnetic resonance and/or positron emission tomography imaging, and a genetic analysis to screen for dementia-related mutations. Genetic status was unknown at the time of initial evaluation. The chosen cases are illustrative of the variety of presentations of psychiatric symptoms in FTD gene carriers. In some cases, a non-neurodegenerative psychiatric illness was diagnosed based on specific symptoms, but the diagnosis may have been inappropriate based on the overall syndrome. In other cases, symptoms closely resembling those seen in non-neurodegenerative psychiatric illness did occur, in some cases immediately preceding the development of dementia, and in other cases developing a decade prior to dementia symptoms...Continue Reading

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Citations

Feb 13, 2016·Frontiers in Aging Neuroscience·Roberta ZanardiniRoberta Ghidoni
Jan 31, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Carmen Andreescu, Howard J Aizenstein
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Jun 18, 2019·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Leila SellamiRobert Laforce
Jan 17, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Emma L van der EndeJohn C Van Swieten
Mar 5, 2020·Brain : a Journal of Neurology·Simon DucharmeYolande Pijnenburg
Jul 27, 2021·Frontiers in Neurology·Nahuel Magrath GuimetKatherine P Rankin

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