Frontotemporal dementia is the leading cause of "true" A-/T+ profiles defined with Aβ42/40 ratio

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Hélène Pouclet-CourtemancheThibaud Lebouvier

Abstract

Patients with positive tauopathy but negative Aβ42 (A-T+) in the cerebrospinal fluid (CSF) represent a diagnostic challenge. The Aβ42/40 ratio supersedes Aβ42 and reintegrates "false" A-T+ patients into the Alzheimer's disease spectrum. However, the biomarker and clinical characteristics of "true" and "false" A-T+ patients remain elusive. Among the 509 T+N+ patients extracted from the databases of three memory clinics, we analyzed T+N+ patients with normal Aβ42 and compared "false" A-T+ with abnormal Aβ42/40 ratio and "true" A-T+ patients with normal Aβ42/40 ratio, before CSF analysis and at follow-up. 24.9% of T+N+ patients had normal Aβ42 levels. Among them, 42.7% were "true" A-T+. "True" A-T+ had lower CSF tauP181 than "false" A-T+ patients. 48.0% of "true" A-T+ patients were diagnosed with frontotemporal lobar degeneration before CSF analysis and 64.0% at follow-up, as compared with 6% in the "false" A-T+ group (P < .0001). Frontotemporal lobar degeneration is probably the main cause of "true" A-T+ profiles.

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Citations

Aug 17, 2021·Journal of Alzheimer's Disease : JAD·Dominique GouillyJérémie Pariente
Sep 4, 2021·Neuroscience Letters·Liara Rizzi, Marcio L F Balthazar

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

SNAP
SAS

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